Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities.

Autor: Tschiche HR; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany. Electronic address: harald.tschiche@bfr.bund.de., Bierkandt FS; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany., Creutzenberg O; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany., Fessard V; French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Fougères Laboratory, Toxicology of contaminants Unit, Fougères, France., Franz R; Fraunhofer Institute for Process Engineering and Packaging (IVV), Freising, Germany., Greiner R; Department of Food Technology and Bioprocess Engineering, Max Rubner-Institut, Karlsruhe, Germany., Gruber-Traub C; Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany., Haas KH; Fraunhofer Institute for Silicate Research (ISC), Würzburg, Germany., Haase A; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany., Hartwig A; Karlsruhe Institute of Technology (KIT), Institute of Applied Biosciences (IAB), Food Chemistry and Toxicology, Germany., Hesse B; European Synchrotron Radiation Facility, Grenoble, France., Hund-Rinke K; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Schmallenberg, Germany., Iden P; Nanid Scientific Consulting, Germany., Kromer C; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany., Loeschner K; National Food Institute, Technical University of Denmark, Lyngby, Denmark., Mutz D; German Federal Institute for Risk Assessment (BfR), Research Strategy and Coordination, Berlin, Germany., Rakow A; Charité - Universitätsmedizin Berlin, Center for Musculoskeletal Surgery, Berlin, Germany; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany., Rasmussen K; European Commission, Joint Research Centre (JRC), Ispra, Italy., Rauscher H; European Commission, Joint Research Centre (JRC), Ispra, Italy., Richter H; Fraunhofer IKTS - Institute for Ceramic Technologies and Systems, Hermsdorf, Germany., Schoon J; Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany., Schmid O; Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany; Institute of Lung Health and Immunity, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Som C; Technology and Society Laboratory, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, Switzerland., Spindler LM; Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany; University of Stuttgart, Institute of Interfacial Process Engineering and Plasma Technology (IGVP), Stuttgart, Germany., Tovar GEM; Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Stuttgart, Germany; University of Stuttgart, Institute of Interfacial Process Engineering and Plasma Technology (IGVP), Stuttgart, Germany., Westerhoff P; Arizona State University, Tempe, AZ, United States of America., Wohlleben W; BASF SE, Advanced Materials Research, Ludwigshafen, Germany., Luch A; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany., Laux P; German Federal Institute for Risk Assessment (BfR), Department of Chemical and Product Safety, Berlin, Germany.
Jazyk: angličtina
Zdroj: NanoImpact [NanoImpact] 2022 Oct; Vol. 28, pp. 100416. Date of Electronic Publication: 2022 Aug 20.
DOI: 10.1016/j.impact.2022.100416
Abstrakt: The widespread integration of engineered nanomaterials into consumer and industrial products creates new challenges and requires innovative approaches in terms of design, testing, reliability, and safety of nanotechnology. The aim of this review article is to give an overview of different product groups in which nanomaterials are present and outline their safety aspects for consumers. Here, release of nanomaterials and related analytical challenges and solutions as well as toxicological considerations, such as dose-metrics, are discussed. Additionally, the utilization of engineered nanomaterials as pharmaceuticals or nutraceuticals to deliver and release cargo molecules is covered. Furthermore, critical pathways for human exposure to nanomaterials, namely inhalation and ingestion, are discussed in the context of risk assessment. Analysis of NMs in food, innovative medicine or food contact materials is discussed. Specific focus is on the presence and release of nanomaterials, including whether nanomaterials can migrate from polymer nanocomposites used in food contact materials. With regard to the toxicology and toxicokinetics of nanomaterials, aspects of dose metrics of inhalation toxicity as well as ingestion toxicology and comparison between in vitro and in vivo conclusions are considered. The definition of dose descriptors to be applied in toxicological testing is emphasized. In relation to potential exposure from different products, opportunities arising from the use of advanced analytical techniques in more unique scenarios such as release of nanomaterials from medical devices such as orthopedic implants are addressed. Alongside higher product performance and complexity, further challenges regarding material characterization and safety, as well as acceptance by the general public are expected.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests which may be considered as potential competing interests. Wendel Wohlleben is an employee of a company producing and marketing Nanomaterials.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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