Dimethoate absorption: A complementary in vitro and in vivo assessment.

Autor: de Andrade ARB; Universidade Federal de Pernambuco, Departamento Ciências farmacêuticas, CEP: 50740-520 Recife, PE, Brazil., de Carvalho DL; Universidade Federal de Pernambuco, Departamento Ciências farmacêuticas, CEP: 50740-520 Recife, PE, Brazil., Kishishita J; Universidade Federal de Pernambuco, Departamento Ciências farmacêuticas, CEP: 50740-520 Recife, PE, Brazil., Pimenta CAP; Universidade Federal de Pernambuco, Departamento Ciências farmacêuticas, CEP: 50740-520 Recife, PE, Brazil., Souza ATM; Universidade Federal de Pernambuco, Departamento Ciências farmacêuticas, CEP: 50740-520 Recife, PE, Brazil., de Santana DP; Universidade Federal de Pernambuco, Departamento Ciências farmacêuticas, CEP: 50740-520 Recife, PE, Brazil., Leal LB; Universidade Federal de Pernambuco, Departamento Ciências farmacêuticas, CEP: 50740-520 Recife, PE, Brazil. Electronic address: leila.leal@nudfac.com.br.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2022 Oct; Vol. 95, pp. 103961. Date of Electronic Publication: 2022 Aug 19.
DOI: 10.1016/j.etap.2022.103961
Abstrakt: This work attempts to evaluate dermal exposure (DE) of farm workers to dimethoate after 4 h of routine application to a lemon plantation. Dimethoate was measured on the workers' clothes as well as in stratum corneum (SC) and in saliva. In vitro permeation tests (IVPT) were performed through rat, pig and human skin and pig buccal, esophageal and sublingual mucosas. The mean of dimethoate DE was 342.19 ± 487.14 mg/d, the percentage of toxic dose per hour was higher than the other pesticides, and the SC penetration factors ranged between 0.5 and 14.81 and 0.05-53.96 % for back of neck and arms respectively. In the supporting IVPT study, dimethoate absorption through human skin was 14.75 % and the default value in the absence of experimental data for this product is 70%. These results show that in family farming the deficiency of correct clothing during the application of pesticides leaves workers more vulnerable.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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