Spreading of alpha-synuclein between different cell types.

Autor: Ruf WP; Department of Neurology, University Clinic, University of Ulm, Ulm, Germany., Meirelles JL; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany., Danzer KM; Department of Neurology, University Clinic, University of Ulm, Ulm, Germany; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany. Electronic address: karin.danzer@dzne.de.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2023 Jan 05; Vol. 436, pp. 114059. Date of Electronic Publication: 2022 Aug 20.
DOI: 10.1016/j.bbr.2022.114059
Abstrakt: Aggregation of alpha-synuclein (α-syn) is central in Parkinson's disease as well as in other synucleinopathies. Recent evidence suggests that not only intracellular aggregation of α-syn plays an important role for disease pathogenesis but also cell-to-cell propagation of α-syn seems to significantly contribute to pathological changes in synucleinopathies. In this mini-review we summarize current aspects of spreading of α-syn between brain cell types and its role in pathology.
(Copyright © 2022. Published by Elsevier B.V.)
Databáze: MEDLINE
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