Solid Xenon Carrier Based on α-Cyclodextrin: Properties, Preparation, and Application.

Autor:	Prokhorov DA; Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia; Institute of Cell Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia., Kutyshenko VP; Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia; Institute of Cell Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia., Tarahovsky YS; Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia; Institute of Cell Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia. Electronic address: tarahov@rambler.ru., Kukushkin NI; Institute of Cell Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia., Khrenov MO; Institute of Cell Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia., Kovtun AL; Russian Foundation for Advanced Research, Russia., Zakharova NM; Institute of Cell Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia.
Jazyk:	angličtina
Zdroj:	Journal of pharmaceutical sciences [J Pharm Sci] 2023 Jan; Vol. 112 (1), pp. 344-349. Date of Electronic Publication: 2022 Aug 20.
DOI:	10.1016/j.xphs.2022.08.014
Abstrakt:	The inert gas xenon (Xe) is increasingly used in medicine as a universal anesthetic, a regulator of cellular metabolism, and a broad-spectrum organoprotector. Commonly utilized Xe inhalation requires expensive equipment that is not universally available. Here we describe the production process and physical characteristics of a solid, highly stable xenon carrier based on α-cyclodextrin (α-CD), developed for oral administration. It was found, that the interaction of α-CD with Xe in an aqueous solution and elevated pressure leads to precipitation of the α-CD-Xe complex. We have discovered three new properties of the resulting complex that promote long-term storage and oral delivery of Xe. (i) At temperatures below 0 °C, the precipitated α-CD-Xe complex containing water is so stable that it allows the removal of water by vacuum freeze-drying (lyophilization). (ii). Lyophilized α-CD-Xe remains stable for months at room temperature. (iii) Upon contact with water, α-CD-Xe rapidly releases gaseous Xe. As revealed in the forced swim test, after oral administration of lyophilized α-CD-Xe to rats, the duration of swimming was significantly increased. The obtained data open up prospects for the development of drugs based on the lyophilized α-CD-Xe complex suitable for storage, transportation, and medical use, including outside the hospital. Competing Interests: Declaration of Competing Interest None. (Copyright © 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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