Renal tubular injury in hyperbilirubinemia: Bile cast nephropathy.
| Autor: | Zhao X; Department of Hepatology, Royal Victoria Hospital, McGill University Health Centre, Montréal, Québec, Canada., Huang R; Department of Hepatology, Royal Victoria Hospital, McGill University Health Centre, Montréal, Québec, Canada., Wong P; Department of Hepatology, Royal Victoria Hospital, McGill University Health Centre, Montréal, Québec, Canada., Fiset PO; Department of Pathology, Royal Victoria Hospital, McGill University Health Centre, Montréal, Québec, Canada., Deschênes M; Department of Hepatology, Royal Victoria Hospital, McGill University Health Centre, Montréal, Québec, Canada. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Canadian liver journal [Can Liver J] 2021 Aug 09; Vol. 4 (3), pp. 332-337. Date of Electronic Publication: 2021 Aug 09 (Print Publication: 2021). |
| DOI: | 10.3138/canlivj-2020-0031 |
| Abstrakt: | The toxic renal accumulation of bile pigment sparked clinical intrigue almost a century ago. More recently, however, the identification of bile casts within renal tubules in patients with liver dysfunction has been largely overlooked. We have reviewed the literature, including natural history, pathophysiology, and potential treatment of bile cast nephropathy (BCN). We report two cases of acute kidney injury (AKI) associated with acute-on-chronic liver failure in which prolonged hyperbilirubinemia and bile cast identification on renal biopsy evoked the diagnosis of BCN. Competing Interests: The authors have nothing to disclose. (Copyright © 2021 Canadian Association for the Study of the Liver.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|