Cyst-like recurrence of retinoblastoma diagnosed by multimodal imaging.

Autor:	Ashkenazy N; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA., Diaz JD; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA., Hansen ED; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA.; John A. Moran Eye Institute, University of Utah, Salt Lake City, UT, USA., Harbour JW; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; University of Texas Southwestern Medical Center, Dallas, TX, USA., Correa ZM; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Jazyk:	angličtina
Zdroj:	American journal of ophthalmology case reports [Am J Ophthalmol Case Rep] 2022 Aug 08; Vol. 27, pp. 101678. Date of Electronic Publication: 2022 Aug 08 (Print Publication: 2022).
DOI:	10.1016/j.ajoc.2022.101678
Abstrakt:	Purpose: To illustrate the diagnosis and management of an atypical, cyst-like recurrence of retinoblastoma. Observations: A 4-month-old boy was diagnosed with Group B retinoblastoma in the right eye, consisting of a 10 x 9 × 3.6 mm retinal tumor temporal to the macula. He was treated with one session of intra-arterial ophthalmic artery chemotherapy using melphalan, followed by three sessions of diode laser transpupillary thermotherapy (TTT), after which complete tumor regression was achieved. 45 weeks after initial treatment, a cystic lesion was detected adjacent to superior margin of the regressed tumor scar. The differential diagnosis included pigment epithelial detachment, retinal gliosis, secondary retinoschisis, and local tumor recurrence. Multimodal imaging including OCT angiography confirmed the diagnosis of local recurrence manifesting as a vascularized cyst-like lesion. Two additional sessions of TTT achieved sustained tumor regression through 16 months of additional follow-up. Conclusions and Importance: Recurrence of retinoblastoma following chemotherapy typically manifests as enlargement of a previously regressed tumor, or seeding into the vitreous or subretinal space. An unusual cyst-like recurrence of retinoblastoma at the margin of a previously regressed tumor was diagnosed by multimodal imaging. Focal diode laser transpupillary thermotherapy was curative. Competing Interests: None of the authors have any financial disclosures relating to the content of this article. (© 2022 Published by Elsevier Inc.)
Databáze:	MEDLINE
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