Cruciferous vegetables as a treasure of functional foods bioactive compounds: Targeting p53 family in gastrointestinal tract and associated cancers.

Autor:	Mitra S; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh., Emran TB; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh.; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh., Chandran D; Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu, India., Zidan BMRM; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh., Das R; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh., Mamada SS; Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia., Masyita A; Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia., Salampe M; Sekolah Tinggi Ilmu Farmasi Makassar, Makassar, Indonesia., Nainu F; Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia., Khandaker MU; Centre for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Subang Jaya, Selangor, Malaysia., Idris AM; Department of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia.; Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi Arabia., Simal-Gandara J; Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, Universidade de Vigo, Ourense, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in nutrition [Front Nutr] 2022 Aug 04; Vol. 9, pp. 951935. Date of Electronic Publication: 2022 Aug 04 (Print Publication: 2022).
DOI:	10.3389/fnut.2022.951935
Abstrakt:	In the past few years, phytochemicals from natural products have gotten the boundless praise in treating cancer. The promising role of cruciferous vegetables and active components contained in these vegetables, such as isothiocyanates, indole-3-carbinol, and isothiocyanates, has been widely researched in experimental in vitro and in vivo carcinogenesis models. The chemopreventive agents produced from the cruciferous vegetables were recurrently proven to affect carcinogenesis throughout the onset and developmental phases of cancer formation. Likewise, findings from clinical investigations and epidemiological research supported this statement. The anticancer activities of these functional foods bioactive compounds are closely related to their ability to upregulate p53 and its related target genes, e.g., p21. As the "guardian of the genome," the p53 family (p53, p63, and p73) plays a pivotal role in preventing the cancer progression associated with DNA damage. This review discusses the functional foods bioactive compounds derived from several cruciferous vegetables and their use in altering the tumor-suppressive effect of p53 proteins. The association between the mutation of p53 and the incidence of gastrointestinal malignancies (gastric, small intestine, colon, liver, and pancreatic cancers) is also discussed. This review contains crucial information about the use of cruciferous vegetables in the treatment of gastrointestinal tract malignancies. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Mitra, Emran, Chandran, Zidan, Das, Mamada, Masyita, Salampe, Nainu, Khandaker, Idris and Simal-Gandara.)
Databáze:	MEDLINE
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