'An experience of meaning' : A 20-year prospective analysis of delusional realities in schizophrenia and affective psychoses.

Autor:	Rosen C; Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States., Harrow M; Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States., Humpston C; Department of Psychology, University of York, York, United Kingdom.; School of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, United Kingdom., Tong L; Advocate Aurora Health, Downers Grove, IL, United States., Jobe TH; Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States., Harrow H; Independent, Chicago, IL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2022 Aug 04; Vol. 13, pp. 940124. Date of Electronic Publication: 2022 Aug 04 (Print Publication: 2022).
DOI:	10.3389/fpsyt.2022.940124
Abstrakt:	Delusions are transdiagnostic and heterogeneous phenomena with varying degrees of intensity, stability, and dimensional attributes where the boundaries between everyday beliefs and delusional beliefs can be experienced as clearly demarcated, fuzzy, or indistinguishable. This highlights the difficulty in defining delusional realities. All individuals in the current study were evaluated at index and at least one of six subsequential follow-ups over 20 years in the Chicago Longitudinal Study. We assessed 16 distinct delusions categorized as thought or thematic delusions. We also examined the probability of recurrence and the relationships between delusions and hallucinations, depression, anxiety, and negative symptoms. The sample consisted of 262 individuals with schizophrenia vs. affective psychosis. Thought delusions were significantly different between groups at all follow-up evaluations except the 20-year timepoint. Thematic delusions were more common than thought delusions and show a significant decreasing pattern. In general, delusional content varied over time. Referential, persecutory, and thought dissemination delusions show the highest probability of recurrence. Hallucinations were the strongest indicator for thought, thematic, and overall delusions. The formation and maintenance of delusions were conceptualized as a multimodal construct consisting of sensory, perceptual, emotional, social, and somatic embodiment of an " experience of meanings ". Given the significant associations between delusions and hallucinations, future work incorporating participatory research is needed to better define and align subjective and objective perspectives. Our research also points to the need for future clinical interventions that specifically evaluate and target the coexistence and entanglement of delusions and hallucinations. Competing Interests: Author LT was employed by Advocate Aurora Health. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Rosen, Harrow, Humpston, Tong, Jobe and Harrow.)
Databáze:	MEDLINE
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