A real-world experience of SARS-CoV-2 infection in a tertiary referral centre of Montréal: Unexpected low prevalence and low mortality.

Autor:	Ruiz I; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Huard G; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Fournier C; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Bissonnette J; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Castel H; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Giard JM; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Villeneuve JP; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Fenyves D; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Marleau D; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Willems B; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Corsilli D; Intensive Care Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Correal F; Pharmacy Department, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Ferreira V; Pharmacy Department, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Martel D; Pharmacy Department, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Mathieu A; Pharmacy Department, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Vincent C; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Bilodeau M; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada.
Jazyk:	angličtina
Zdroj:	Canadian liver journal [Can Liver J] 2021 Nov 11; Vol. 4 (4), pp. 391-400. Date of Electronic Publication: 2021 Nov 11 (Print Publication: 2021).
DOI:	10.3138/canlivj-2021-0022
Abstrakt:	Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with chronic liver disease (CLD) and liver transplant (LT) recipients remains a concern. The aim of this study was to report the impact of coronavirus disease 2019 (COVID-19) infection among patients at the tertiary health care centre Centre hospitalier de l'Université de Montréal (CHUM) during the first wave of the SARS-CoV-2 pandemic. Methods: This real-world, retrospective cohort included all patients admitted to our liver unit and/or seen as an outpatient with CLD with or without cirrhosis and/or LT recipients who tested positive to SARS-CoV-2 infection. Cases were considered positive as defined by the detection of SARS-CoV-2 by reverse-transcription polymerase chain reaction (RT-PCR) on nasopharyngeal swabs. Results: Between April 1 and July 31, 2020, 5,637 were admitted to our liver unit and/or seen as outpatient. Among them, 42 were positive for SARS-CoV-2. Twenty-two patients had CLD without cirrhosis while 16 patients had cirrhosis at the time of the infection (13, 2, and 1 with Child-Pugh A, B, and C scores, respectively). Four were LT recipients. Overall, 15 of 42 patients (35.7%) were hospitalized; among them, 7 of 42 (16.7%) required respiratory support and 4 of 42 (9.5%) were transferred to the intensive care unit. Only 4 of 42 (9.5%) patients died: 2 with CLD without cirrhosis and 2 with CLD with cirrhosis. Overall survival was 90.5%. Conclusion: This real-world study demonstrates an unexpectedly low prevalence and low mortality in the context of SARS-CoV-2 infection among patients with CLD with or without cirrhosis and LT recipients. Competing Interests: I Ruiz is a recipient of a fellowship grant from the Fondation du CHUM, Montréal, Québec, Canada. D Martel has served as an advisor and/or speaker for AbbVie and Gilead. The rest of the authors have no conflicts of interest to declare. (Copyright © 2021 Canadian Association for the Study of the Liver.)
Databáze:	MEDLINE
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