Impact of Non-viral Coinfections on Mortality of Severely Ill COVID-19 Patients in Dubai.

Autor:	Nadeem R; Intensive Care Medicine, Dubai Hospital, Dubai, ARE., Rafeeq A; Medicine, Dubai Health Authority, Dubai, ARE., Aga AA; Medicine, Dubai Health Authority, Dubai, ARE., Siddiqua A; Medicine, Dubai Health Authority, Dubai, ARE., Sharma E; Anesthesiology, Dubai Hospital, Dubai, ARE., Anwer D; Intensive Care Unit, Dubai Hospital, Dubai, ARE., Kafeel Khan M; Pediatric Critical Care Medicine, Dubai Hospital, Dubai, ARE., Abdulla Mohammed Hussein M; Pediatric Critical Care Medicine, Dubai Hospital, Dubai, ARE., Omar Alshaikh SayedAhmed Y; Pediatrics Medicine, Dubai Hospital, Dubai, ARE., Ahmad Dar F; Cardiac Surgery, Dubai Health Authority, Dubai, ARE.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Jul 18; Vol. 14 (7), pp. e26977. Date of Electronic Publication: 2022 Jul 18 (Print Publication: 2022).
DOI:	10.7759/cureus.26977
Abstrakt:	Background: Coronavirus disease 2019 (COVID-19) infections may have been associated with secondary infection. Community-acquired or hospital-acquired such infections affect clinical outcomes. We performed a retrospective study to evaluate the impact of these infections on clinical outcomes. Methods: This was a retrospective analysis of all consecutive patients with COVID-19 admitted to the intensive care unit (ICU) of Dubai hospital. Results: Patients with secondary non-viral infections (SNIs) have higher mortality than patients without SNIs (57.3% vs. 43.7%, p=0.037). Patients with SNIs had more days on mechanical ventilation (MV) 19(11-27) vs. 5(2-10) p<0.001, more LOSICU 22 (15-33) vs. 7 (2-11) p<0.001, and more length of stay in hospital (LOSH) 28 (18-45) vs. 11.5 (6-19), p<0.001. Multiple logistic regression analyses showed that SNIs do not predict mortality. Linear logistic regression analysis showed patients with SNIs have increased length of stay in ICUs (LOSICUs), length of stay in hospitals (LOSHs), and prolonged needs for MV. Conclusion: SNIs are high in patients admitted to ICU for COVID-19 acute respiratory distress syndrome (ARDS). Although they do not impact mortality, they prolong the need for MV, LOSICU, and LOSH. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Nadeem et al.)
Databáze:	MEDLINE
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