Krüppel-like factors family regulation of adipogenic markers genes in bovine cattle adipogenesis.

Autor: Raza SHA; College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, PR China. Electronic address: dr.haiderabbasraza@gmail.com., Pant SD; School of Agricultural, Environmental and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia., Wani AK; Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Punjab, (144411), India., Mohamed HH; Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, Egypt., Khalifa NE; Department of Physiology, Faculty of Veterinary Medicine, Fuka, Matrouh University, Matrouh, 51744, Egypt., Almohaimeed HM; Department of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman University, P.O.Box 84428, Riyadh, 11671, Saudi Arabia., Alshanwani AR; Physiology Department, College of Medicine, King Saud University, Saudi Arabia., Assiri R; Department of Basic Medical Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, 11671, Saudi Arabia., Aggad WS; Department of Anatomy, College of Medicine, University of Jeddah, P.O. Box 8304, Jeddah, 23234, Saudi Arabia., Noreldin AE; Histology and Cytology Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, Egypt., Abdelnour SA; Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt., Wang Z; Shanghai Collaborative Innovation Center of Agri-Seeds/School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, PR China. Electronic address: wangz@sjtu.edu.cn., Zan L; College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, PR China. Electronic address: zanlinsen@163.com.
Jazyk: angličtina
Zdroj: Molecular and cellular probes [Mol Cell Probes] 2022 Oct; Vol. 65, pp. 101850. Date of Electronic Publication: 2022 Aug 18.
DOI: 10.1016/j.mcp.2022.101850
Abstrakt: Intramuscular fat (IMF) content is a crucial determinant of meat quality traits in livestock. A network of transcription factors act in concert to regulate adipocyte formation and differentiation, which in turn influences intramuscular fat. Several genes and associated transcription factors have been reported to influence lipogenesis and adipogenesis during fetal and subsequent growth stage. Specifically in cattle, Krüppel-like factors (KLFs), which represents a family of transcription factors, have been reported to be involved in adipogenic differentiation and development. KLFs are a relatively large group of zinc-finger transcription factors that have a variety of functions in addition to adipogenesis. In mammals, the participation of KLFs in cell development and differentiation is well known. Specifically in the context of adipogenesis, KLFs function either as positive (KLF4, KLF5, KLF6, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF14 and KLF15) or negative organizers (KLF2, KLF3 and KLF7), by a variety of different mechanisms such as crosstalk with C/EBP and PPARγ. In this review, we aim to summarize the potential functions of KLFs in regulating adipogenesis and associated pathways in cattle. Furthermore, the function of known bovine adipogenic marker genes, and associated transcription factors that regulate the expression of these marker genes is also summarized. Overall, this review will provide an overview of marker genes known to influence bovine adipogenesis and regulation of expression of these genes, to provide insights into leveraging these genes and transcription factors to enhance breeding programs, especially in the context of IMF deposition and meat quality.
Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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