Pathogens susceptible to tetracycline are also susceptible to omadacycline: tetracycline as a one-sided surrogate to predict omadacycline susceptible pathogens.

Autor: Serio AW; Paratek Pharmaceuticals, Inc., King of Prussia, PA, USA. Electronic address: Alisa.serio@paratekpharma.com., Keepers TR; Paratek Pharmaceuticals, Inc., King of Prussia, PA, USA., Wright K; Paratek Pharmaceuticals, Inc., King of Prussia, PA, USA., Anastasiou D; Paratek Pharmaceuticals, Inc., King of Prussia, PA, USA.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2022 Nov; Vol. 104 (3), pp. 115785. Date of Electronic Publication: 2022 Jul 28.
DOI: 10.1016/j.diagmicrobio.2022.115785
Abstrakt: This study used surveillance data from a global program of clinical bacterial isolates to determine whether a tetracycline susceptible result can be used to predict an omadacycline susceptible result. Categorical agreement, very major error rates, and minor error rates were calculated for Staphylococcus aureus (MSSA and MRSA; n=38,364), S. lugdunensis (n=335), Streptococcus pneumoniae (n=11,725), S. pyogenes (n=3,390), S. anginosus group (n=622), Haemophilus spp. (n=6,419), Enterococcus faecalis (n=7,065), Klebsiella pneumoniae (n=10,313), and Enterobacter cloacae (n=4,418). Across the organisms, for which omadacycline has an FDA breakpoint established, a tetracycline susceptible result showed ≥96.3% categorical agreement in predicting an omadacycline susceptible result. The rates of very major errors were below the guideline-suggested level (<1.5%). Omadacycline retained activity against most (88.7-100% Gram-positive and 54-98.6% Gram-negative) tetracycline-resistant isolates. For laboratories that do not have the capability to perform susceptibility testing for omadacycline, one-sided surrogate testing for tetracycline can be a practical alternative.
Competing Interests: Declaration of competing interests AWS, KW, and DA are employees and shareholders of Paratek Pharmaceuticals, Inc. TRK is a former consultant of Paratek Pharmaceuticals, Inc.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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