Patients experienced serious adverse reactions within one hour of hematopoietic stem-cell infusion.

Autor: Meric N; Faculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Kütahya University of Health Sciences, Kütahya, Turkey. Electronic address: nesli7726@gmail.com., Parmaksız A; Faculty of Medicine, Istanbul Health and Technology University, Istanbul, Turkey., Gulbas Z; Anadolu Health Center, Bone Marrow Transplantation Center, Kocaeli, Turkey.
Jazyk: angličtina
Zdroj: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine [Transfus Clin Biol] 2023 Feb; Vol. 30 (1), pp. 82-86. Date of Electronic Publication: 2022 Aug 17.
DOI: 10.1016/j.tracli.2022.08.141
Abstrakt: Methods: SARs were examined occurred within 1 hour after initiating HSC product infusions in all HSCT done in Turkey's Anadolu Medical Center Hospital accredited for HSCTs between 2013 and 2015, targeting 315 patients.
Results: SARs were carefully evaluated in this study based on a comparison of the amount of stem cells infused, age, frozen sample (FS) / non-frozen samples (NFS) between HSCs sources. Rate of SARs is significantly higher in FS infusions supports the hypothesis that DMSO plays an important role in the development of SAR.
Conclusion: The rate of SARs is significantly higher in infusions given using FSs confirms the hypothesis that the preservative agent DMSO plays an important role in the development of SAR. Our study provides guidance for future studies on the necessity of reducing the amount of DMSO in the HSCT product and using other alternative freezing agents instead of DMSO.
(Copyright © 2022 Société française de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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