Prevalence and Clinico-Radiologic Spectrum of Intracranial Atherosclerotic Disease-Related Stroke: An Observation from a Single Center in Saudi Arabia.

Autor:	Zafar A; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University., Albakr A; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University., Shahid R; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University., Alkhamis F; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University., Alabdali M; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University., Aljaafari D; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University., Nazish S; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University., Ishaque N; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University., Soltan NM; Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University., Msmar AH; Department of Research Statistical Support, Deanship of Scientific Research., Al-Suhibani SS; Department of Radiology, College of Medicine., Al-Jehani H; Department of Neurosurgery, Critical Care Medicine, and Interventional Radiology. King Fahd University Hospital, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia.
Jazyk:	angličtina
Zdroj:	The neurologist [Neurologist] 2023 May 01; Vol. 28 (3), pp. 173-179. Date of Electronic Publication: 2023 May 01.
DOI:	10.1097/NRL.0000000000000463
Abstrakt:	Background: Intracranial atherosclerotic disease (ICAD) is an important etiologic subtype of acute ischemic stroke (AIS). However, little direct evidence is available regarding ICAD-related stroke in Saudi Arabia (SA). This study aimed to identify the prevalence and describe the clinico-radiological spectrum of ICAD-related AIS in a SA cohort. Methods: This was a hospital-based retrospective study enrolling patients with ICAD-related AIS between 2017 and 2020. The electronic charts were reviewed. The mechanisms of stroke were identified as artery-to-artery embolization (AAE), in situ thrombotic occlusion, hypoperfusion, or perforator branch occlusion. Pearson's χ 2 test was performed to calculate the P values to establish the statistical significance of factors that could correlate with the mechanisms of stroke and functional outcome. Results: ICAD was found in 133 of AIS comprising 26% of total. Data from all patients were reviewed. Left ICA (25%) was the most frequently affected vessel. Territorial pattern (63.9%) was the most common infarct pattern, and AAE (44.3%) was the most common underlying mechanism. Perforator branch occlusion was more prevalent in women than in men. Malignant and hemorrhagic transformation ( P =0.00) were more prevalent in the AAE group. Left-sided vascular involvement was statistically associated with unfavorable outcomes than the right ( P =0.019). Conclusions: The prevalence of ICAD in our cohort from Western Asia did not differ from that in Southern Asia. ICA involvement was observed more frequently than previously reported. Further research from SA is required to better understand ICAD-related strokes in this region. Competing Interests: The authors declare no conflict of interest. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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