Pharmacological Activities of the Genus Passiflora (Passifloraceae): A Patent Review.

Autor:	Pereira Leal AEB; Postgraduate Program in Biotechnology, State University of Feira de Santana, Feira de Santana, Brazil.; Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Brazil., de Lavor ÉM; Postgraduate Program in Biotechnology, State University of Feira de Santana, Feira de Santana, Brazil.; Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Brazil., de Menezes Barbosa J; Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Brazil., de Moura Fontes Araújo MT; Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Brazil., Dos Santos Cerqueira Alves C; Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Brazil., de Oliveira Júnior RG; Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Brazil., de Lima ÁAN; Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal, Brazil., da Silva Almeida JRG; Postgraduate Program in Biotechnology, State University of Feira de Santana, Feira de Santana, Brazil.; Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Brazil.
Jazyk:	angličtina
Zdroj:	Current topics in medicinal chemistry [Curr Top Med Chem] 2022; Vol. 22 (28), pp. 2315-2328.
DOI:	10.2174/1568026622666220819160923
Abstrakt:	Background: Passiflora L. is a genus belonging to the Passifloraceae family, with many species widely used in folk medicine and several pharmacological activities described in the scientific literature, being a major target for the development of new therapeutic products. Studies have identified several bioactive compounds in their composition as responsible for these activities, mainly C-glycoside flavonoids. Objective: The aim of this study was to carry out a review of patents related to the genus and its application in several pharmacological activities, important for the development of new drugs and formulations. Methods: The search was carried out in 5 specialized databases, INPI, EPO, WIPO, Latipat and Derwent, using the term 'Passiflora' combined with 'A61K and A61P', subclasses of section A of the International Patent Classification (IPC), which are destined to medical, dental or hygienic purposes, and therapeutic activity of chemical compounds or medicinal preparation, respectively. Results: 1,198 patents citing the genus in the title or abstract have been found, 508 being duplicates. After exclusion and inclusion criteria, 23 patents written in English, Portuguese and Spanish were selected, which demonstrated biological assays in vivo with species of Passiflora as the only active constituent or incorporated in formulations with other compounds. Conclusion: The findings of this search showed growing interest in research and industrial areas in the pharmaceutical development with species of Passiflora, suggesting that the different bioactive compounds present in the genus can be considered as an important tool for the development of new effective and safe products with pharmacological potential. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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