SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy.

Autor: Jin JC; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Department of Pediatrics, Division of Newborn Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA., Ananthanarayanan A; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Department of Pediatrics, Division of Newborn Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA., Brown JA; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Department of Pediatrics, Division of Newborn Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA., Rager SL; Department of Pediatrics, Division of Newborn Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA., Bram Y; Division of Gastroenterology and Hepatology, Department of Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA.; Department of Biophysics, Physiology, and Systems Biology, Weill Cornell Medicine, New York, NY, USA., Sanidad KZ; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Department of Pediatrics, Division of Newborn Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA., Amir M; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Department of Pediatrics, Division of Newborn Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA., Baergen RN; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Stuhlmann H; Department of Pediatrics, Division of Newborn Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA.; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA., Schwartz RE; Division of Gastroenterology and Hepatology, Department of Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA.; Department of Biophysics, Physiology, and Systems Biology, Weill Cornell Medicine, New York, NY, USA., Perlman JM; Department of Pediatrics, Division of Newborn Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA., Zeng MY; Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA. myz4001@med.cornell.edu.; Department of Pediatrics, Division of Newborn Medicine, New York-Presbyterian-Weill Cornell Medicine, New York, NY, USA. myz4001@med.cornell.edu.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2023 Apr; Vol. 93 (5), pp. 1375-1382. Date of Electronic Publication: 2022 Aug 19.
DOI: 10.1038/s41390-022-02266-7
Abstrakt: Background: In utero transmission of SARS coronavirus 2 (SARS-CoV-2) has not been fully investigated. We investigated whether newborns of mothers with COVID-19 during pregnancy might harbor SARS-CoV-2 in the gastrointestinal tract.
Methods: This cohort study investigated stool from 14 newborns born at 25-41 weeks admitted at delivery to our urban academic hospital whose mothers had COVID-19 during pregnancy. Eleven mothers had COVID-19 resolved more than 10 weeks before delivery. Newborn stool was evaluated for SARS-CoV-2 RNA, Spike protein, and induction of inflammatory cytokines interleukin-6 (IL-6) and interferon-γ (IFN-γ) in macrophages.
Results: Despite negative SARS CoV-2 nasal PCRs from all newborns, viral RNAs and Spike protein were detected in the stool of 11 out of 14 newborns as early as the first day of life and increased over time in 6. Stool homogenates from all 14 newborns elicited elevated inflammatory IL-6 and IFN-γ from macrophages. Most newborns were clinically well except for one death from gestational autoimmune liver disease and another who developed necrotizing enterocolitis.
Conclusions: These findings suggest in utero transmission of SARS-CoV-2 and possible persistent intestinal viral reservoirs in the newborns. Further investigation is required to understand the mechanisms and their clinical implications.
Impact: SARS-CoV-2 RNAs or Spike protein was detected in the stool of 11 out of 14 preterm newborns born to mothers with resolved COVID-19 weeks prior to delivery despite negative newborn nasal PCR swabs. These novel findings suggest risk of in utero SARS-CoV-2 transmission to the fetal intestine during gestation. The presence of SARS-CoV-2 RNAs and Spike protein in the intestines of newborns may potentially impact the development of the gut microbiome and the immune system; the long-term health impact on the preterm infants should be further investigated.
(© 2022. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)
Databáze: MEDLINE
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