Could Tailored Chirp Stimuli Benefit Measurement of the Supra-threshold Auditory Brainstem Wave-I Response?
Autor: | de Boer J; Hearing Sciences, School of Medicine, Mental Health & Clinical Neurosciences, University of Nottingham, Science Road, Nottingham, NG7 2RD, UK.; Nottingham Biomedical Research Centre, Queens Medical Centre, Hearing Theme, Nottingham, NG7 2UH, UK., Hardy A; Hearing Sciences, School of Medicine, Mental Health & Clinical Neurosciences, University of Nottingham, Science Road, Nottingham, NG7 2RD, UK.; School of Psychology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK., Krumbholz K; Hearing Sciences, School of Medicine, Mental Health & Clinical Neurosciences, University of Nottingham, Science Road, Nottingham, NG7 2RD, UK. Katrin.Krumbholz@nottingham.ac.uk.; Nottingham Biomedical Research Centre, Queens Medical Centre, Hearing Theme, Nottingham, NG7 2UH, UK. Katrin.Krumbholz@nottingham.ac.uk. |
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Jazyk: | angličtina |
Zdroj: | Journal of the Association for Research in Otolaryngology : JARO [J Assoc Res Otolaryngol] 2022 Dec; Vol. 23 (6), pp. 787-802. Date of Electronic Publication: 2022 Aug 19. |
DOI: | 10.1007/s10162-022-00848-0 |
Abstrakt: | Auditory brainstem responses (ABRs) to broadband clicks are strongly affected by dyssynchrony, or "latency dispersion", of their frequency-specific cochlear contributions. Optimized chirp stimuli, designed to compensate for cochlear dispersion, can afford substantial increase in broadband ABR amplitudes, particularly for the prominent wave-V deflection. Reports on the smaller wave I, however, which may be useful for measuring cochlear synaptopathy, have been mixed. This study aimed to test previous claims that ABR latency dispersion differs between waves I and V, and between males and females, and thus that using wave- and/or sex-tailored chirps may provide more reliable wave-I benefit. Using the derived-band technique, we measured responses from frequency-restricted (one-octave-wide) cochlear regions to energy-matched click and chirp stimuli. The derived-band responses' latencies were used to assess any wave- and/or sex-related dispersion differences across bands, and their amplitudes, to evaluate any within-band dispersion differences. Our results suggest that sex-related dispersion difference within the lowest-frequency cochlear regions (< 1 kHz), where dispersion is generally greatest, may be a predominant driver of the often-reported sex difference in broadband ABR amplitude. At the same time, they showed no systematic dispersion difference between waves I and V. Instead, they suggest that reduced chirp benefit on wave I may arise as a result of chirp-induced desynchronization of on- and off-frequency responses generated at the same cochlear places, and resultant reduction in response contributions from higher-frequency cochlear regions, to which wave I is thought to be particularly sensitive. (© 2022. The Author(s).) |
Databáze: | MEDLINE |
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