| Autor: |
Manuguri S; Department of Neuroscience and Biomedical Engineering, School of Science, Aalto University, FI-00076 Aalto, Finland., Nguyen MK; Department of Neuroscience and Biomedical Engineering, School of Science, Aalto University, FI-00076 Aalto, Finland.; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet St., Dist. 10, Ho Chi Minh City 70000, Vietnam.; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc Dist., Ho Chi Minh City 756100, Vietnam., Loo J; Department of Neuroscience and Biomedical Engineering, School of Science, Aalto University, FI-00076 Aalto, Finland., Natarajan AK; Department of Neuroscience and Biomedical Engineering, School of Science, Aalto University, FI-00076 Aalto, Finland., Kuzyk A; Department of Neuroscience and Biomedical Engineering, School of Science, Aalto University, FI-00076 Aalto, Finland. |
| Abstrakt: |
Since its discovery in 2006, the DNA origami technique has revolutionized bottom-up nanofabrication. This technique is simple yet versatile and enables the fabrication of nanostructures of almost arbitrary shapes. Furthermore, due to their intrinsic addressability, DNA origami structures can serve as templates for the arrangement of various nanoscale components (small molecules, proteins, nanoparticles, etc.) with controlled stoichiometry and nanometer-scale precision, which is often beyond the reach of other nanofabrication techniques. Despite the multiple benefits of the DNA origami technique, its applicability is often restricted by the limited stability in application-specific conditions. This Review provides an overview of the strategies that have been developed to improve the stability of DNA-origami-based assemblies for potential biomedical, nanofabrication, and other applications. |
