Developmental genetic effects on externalizing behavior and alcohol use: Examination across two longitudinal samples.

Autor:	Elam KK; Department of Applied Health Science, Indiana University, Bloomington, IN, USA., Bountress KE; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Ha T; Department of Psychology, Arizona State University, Tempe, AZ, USA., Shaw DS; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA., Wilson MN; Department of Psychology, University of Virginia, Charlottesville, VA, USA., Aliev F; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Dick DM; Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Lemery-Chalfant K; Department of Psychology, Arizona State University, Tempe, AZ, USA.
Jazyk:	angličtina
Zdroj:	Development and psychopathology [Dev Psychopathol] 2024 Feb; Vol. 36 (1), pp. 82-91. Date of Electronic Publication: 2022 Aug 19.
DOI:	10.1017/S0954579422000980
Abstrakt:	Externalizing behavior in early adolescence is associated with alcohol use in adolescence and early adulthood and these behaviors often emerge as part of a developmental sequence. This pattern can be the result of heterotypic continuity, in which different behaviors emerge over time based on an underlying shared etiology. In particular, there is largely a shared genetic etiology underlying externalizing and substance use behaviors. We examined whether polygenic risk for alcohol use disorder predicted (1) externalizing behavior in early adolescence and alcohol use in adolescence in the Early Steps Multisite sample and (2) externalizing behavior in adolescence and alcohol use in early adulthood in the Project Alliance 1 (PAL1) sample. We examined associations separately for African Americans and European Americans. When examining European Americans in the Early Steps sample, greater polygenic risk was associated with externalizing behavior in early adolescence. In European Americans in PAL1, we found greater polygenic risk was associated with alcohol use in early adulthood. Effects were largely absent in African Americans in both samples. Results imply that genetic predisposition for alcohol use disorder may increase risk for externalizing and alcohol use as these behaviors emerge developmentally.
Databáze:	MEDLINE
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