Elucidating the coordination chemistry of the radium ion for targeted alpha therapy.

Autor:	Ivanov AS; Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA. ivanova@ornl.gov., Simms ME; Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA. ivanova@ornl.gov., Bryantsev VS; Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA. ivanova@ornl.gov., Benny PD; Radioisotope Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA., Griswold JR; Radioisotope Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA., Delmau LH; Radioisotope Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA., Thiele NA; Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA. ivanova@ornl.gov.
Jazyk:	angličtina
Zdroj:	Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Sep 01; Vol. 58 (71), pp. 9938-9941. Date of Electronic Publication: 2022 Sep 01.
DOI:	10.1039/d2cc03156f
Abstrakt:	The coordination chemistry of Ra 2+ is poorly defined, hampering efforts to design effective chelators for 223 Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra 2+ with the biomedically-relevant chelators DOTA and macropa. Our work reveals the highest affinity chelator to date for Ra 2+ and advances our understanding of key factors underlying complex stability and selectivity for this underexplored ion.
Databáze:	MEDLINE
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