Endolysins against Streptococci as an antibiotic alternative.

Autor:	Wong KY; Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia., Megat Mazhar Khair MH; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Song AA; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Masarudin MJ; Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Chong CM; Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, Selangor, Malaysia., In LLA; Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia., Teo MYM; Department of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2022 Aug 02; Vol. 13, pp. 935145. Date of Electronic Publication: 2022 Aug 02 (Print Publication: 2022).
DOI:	10.3389/fmicb.2022.935145
Abstrakt:	Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial lysis. Endolysins have been extensively researched in different fields, including medicine, food, and agricultural applications. While the target specificity of various endolysins varies greatly between species, this current review focuses specifically on streptococcal endolysins. Streptococcus spp. causes numerous infections, from the common strep throat to much more serious life-threatening infections such as pneumonia and meningitis. It is reported as a major crisis in various industries, causing systemic infections associated with high mortality and morbidity, as well as economic losses, especially in the agricultural industry. This review highlights the types of catalytic and cell wall-binding domains found in streptococcal endolysins and gives a comprehensive account of the lytic ability of both native and engineered streptococcal endolysins studied thus far, as well as its potential application across different industries. Finally, it gives an overview of the advantages and limitations of these enzyme-based antibiotics, which has caused the term enzybiotics to be conferred to it. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Wong, Megat Mazhar Khair, Song, Masarudin, Chong, In and Teo.)
Databáze:	MEDLINE
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