Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies.

Autor: Trøseid M; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Dahl TB; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Division of Critical Care and Emergencies, Oslo University Hospital, Oslo, Norway., Holter JC; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Microbiology, Oslo University Hospital, Oslo, Norway., Kildal AB; Department of Anesthesiology and Intensive Care, University Hospital of North Norway, Tromsø, Norway., Murphy SL; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Yang K; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway., Quiles-Jiménez A; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway., Heggelund L; Department of Internal Medicine, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.; Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway., Müller KE; Department of Internal Medicine, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway., Tveita A; Department of Internal Medicine, Baerum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.; Division of Laboratory Medicine, Department of Immunology, Oslo University Hospital, Oslo, Norway., Michelsen AE; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Bøe S; Department of Anesthesiology and Intensive Care, Hammerfest County Hospital, Hammerfest, Norway., Holten AR; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Acute Medicine, Oslo University Hospital, Oslo, Norway., Hoel H; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Department of Internal Medicine, Lovisenberg Diakonal Hospital, Oslo, Norway., Mathiessen A; Department of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway., Aaløkken TM; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Radiology and Nuclear Medicine, Oslo University Hospital Ullevål, Oslo, Norway., Fevang B; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway., Granerud BK; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Microbiology, Oslo University Hospital, Oslo, Norway., Tonby K; Department of Infectious Diseases, Oslo University Hospital Ullevål, Oslo, Norway., Henriksen KN; Hospital Pharmacies, South-Eastern Norway Enterprise, Oslo, Norway.; Department of Hematology, Oslo University Hospital Rikshospitalet, Oslo, Norway., Lerum TV; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Pulmonary Medicine, Oslo University Hospital Ullevål, Oslo, Norway., Müller F; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Microbiology, Oslo University Hospital, Oslo, Norway., Skjønsberg OH; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Pulmonary Medicine, Oslo University Hospital Ullevål, Oslo, Norway., Barratt-Due A; Division of Critical Care and Emergencies, Oslo University Hospital, Oslo, Norway.; Division of Laboratory Medicine, Department of Immunology, Oslo University Hospital, Oslo, Norway., Dyrhol-Riise AM; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Infectious Diseases, Oslo University Hospital Ullevål, Oslo, Norway., Aukrust P; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Halvorsen B; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Ueland T; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Clinical Medicine, Thrombosis Research and Expertise Center (TREC), UiT-The Arctic University of Norway, Tromsø, Norway.
Jazyk: angličtina
Zdroj: Journal of internal medicine [J Intern Med] 2022 Nov; Vol. 292 (5), pp. 816-828. Date of Electronic Publication: 2022 Aug 18.
DOI: 10.1111/joim.13549
Abstrakt: Background: T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown.
Objectives: To investigate whether T-cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID-19.
Methods: Plasma and serum from two Norwegian cohorts of hospitalized patients with COVID-19 (n = 414) were analyzed for soluble (s) markers of T-cell activation (sCD25) and exhaustion (sTim-3) during hospitalization and follow-up.
Results: Both markers were strongly associated with acute respiratory failure, but only sTim-3 was independently associated with 60-day mortality. Levels of sTim-3 remained elevated 3 and 12 months after hospitalization and were associated with pulmonary radiological pathology after 3 months.
Conclusion: Our findings suggest prolonged T-cell exhaustion is an important immunological sequela, potentially related to long-term outcomes after severe COVID-19.
(© 2022 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.)
Databáze: MEDLINE
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