Prognostic value of myopic disk deformation in myopic choroidal neovascularization: A 6-year follow-up study.

Autor:	Han YE; Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Kim YJ; Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Yang HS; Department of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, South Korea., Moon BG; Department of Ophthalmology, Seoul Shinsegae Eye Center, Eui Jung Bu, South Korea., Lee JY; Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Kim JG; Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Yoon YH; Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2022 Aug 01; Vol. 9, pp. 947632. Date of Electronic Publication: 2022 Aug 01 (Print Publication: 2022).
DOI:	10.3389/fmed.2022.947632
Abstrakt:	Purpose: To evaluate the clinical characteristics of myopic choroidal neovascularization (mCNV) according to peripapillary atrophy (PPA) and optic disk tilt and to explore whether those myopic disk deformations are associated with the prognosis of mCNV. Methods: Patients with subfoveal mCNV who received intravitreal bevacizumab injection and followed for ≥3 years were included. PPA was quantified as area of the ß-zone PPA/disk area ratio (PDR) and optic disk tilt as the tilt ratio (the longest/shortest disk diameter). We compared the clinical characteristics in terms of PDR and tilt ratio and identified the poor prognostic factors using Logistic regression and Cox proportional hazard model. Results: Among 80 eyes of 80 patients, 29 (36.30%) eyes developed macular atrophy during 80.71 ± 34.76 months. PDR and tilt ratio are strongly correlated with each other ( P = 0.004). Higher PDR showed significant correlations with longer axial length ( P = 0.013), worse baseline and final VA ( P = 0.007 and P = 0.047), and thinner subfoveal choroidal thickness ( P = 0.039), while higher tilt ratio showed significant correlations only with longer axial length ( P = 0.036). High PDR was also an independent risk factor for both macular atrophy (OR = 2.257, P < 0.001) and poor visual outcome (HR = 1.174, P = 0.007), while high disk tilt ratio was not. Conclusion: Subfoveal mCNV with higher ß-zone PPA area/disk area ratio had worse functional and structural outcomes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Han, Kim, Yang, Moon, Lee, Kim and Yoon.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu