Early predictors of abnormal MRI patterns in asphyxiated infants: S100B protein urine levels.

Autor:	Bersani I; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù; Children's Hospital, Rome, Italy., Gasparroni G; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., Bashir M; Department of Neonatology, Cairo University, Cairo, Egypt., Aboulgar H; Department of Neonatology, Cairo University, Cairo, Egypt., Mufeed H; Department of Neonatology, Cairo University, Cairo, Egypt., Iskander I; Department of Neonatology, Cairo University, Cairo, Egypt., Kornacka M; Department of Neonatology and Intensive Care of Neonate, Warsaw University, Warsaw, Poland., Gruzfeld D; Department of Neonatology and Intensive Care of Neonate, Warsaw University, Warsaw, Poland., Dotta A; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù; Children's Hospital, Rome, Italy., Campi F; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù; Children's Hospital, Rome, Italy., Longo D; Neuroradiology Unit, Department of Imaging, Bambino Gesù; Children's Hospital, Rome, Italy., Savarese I; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù; Children's Hospital, Rome, Italy., Braguglia A; Department of Neonatology, Neonatal Intensive Care Unit, Bambino Gesù; Children's Hospital, Rome, Italy., Tina LG; Department of Maternal Fetal and Neonatal Health, G. Garibaldi Hospital, Catania, Italy., Nigro F; Department of Maternal Fetal and Neonatal Health, G. Garibaldi Hospital, Catania, Italy., Serpero L; Department of Maternal Fetal and Neonatal Medicine C. Arrigo Children's Hospital, Alessandria, Italy., Strozzi MC; Department of Maternal Fetal and Neonatal Medicine C. Arrigo Children's Hospital, Alessandria, Italy., Maconi A; Department of Maternal Fetal and Neonatal Medicine C. Arrigo Children's Hospital, Alessandria, Italy., Ianniello P; Department of Maternal Fetal and Neonatal Medicine C. Arrigo Children's Hospital, Alessandria, Italy., Di Battista C; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., D'Adamo E; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., Gavilanes D; Department of Pediatrics and Neonatology, Maastricht University, Maastricht, The Netherlands., Gazzolo D; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Jazyk:	angličtina
Zdroj:	Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2022 Aug 18; Vol. 60 (11), pp. 1745-1752. Date of Electronic Publication: 2022 Aug 18 (Print Publication: 2022).
DOI:	10.1515/cclm-2022-0559
Abstrakt:	Objectives: The early detection and stratification of asphyxiated infants at higher risk for impaired neurodevelopment is challenging. S100B protein is a well-established biomarker of brain damage, but lacks conclusive validation according to the "gold standard" methodology for hypoxic-ischemic encephalopathy (HIE) prognostication, i.e. brain MRI. The aim of the present study was to investigate the predictive role of urinary S100B concentrations, assessed in a cohort of HIE infants receiving therapeutic hypothermia (TH), compared to brain MRI. Methods: Assessment of urine S100B concentrations was performed by immunoluminometric assay at first void and at 4, 8, 12, 16, 20, 24, 48, 72, 96, 108 and 120-h after birth. Neurologic evaluation, routine laboratory parameters, amplitude-integrated electroencephalography, and cerebral ultrasound were performed according to standard protocols. Brain MRI was performed at 7-10 days of life. Results: Overall, 74 HIE neonates receiving TH were included in the study. S100B correlated, already at first void, with the MRI patterns with higher concentrations in infants with the most severe MRI lesions. Conclusions: High S100B urine levels soon after birth constitute trustable predictors of brain injury as confirmed by MRI. Results support the reliability of S100B in clinical daily practice and open the way to its inclusion in the panel of parameters used for the selection of cases suitable for TH treatment. (© 2022 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu