Vitamin D intakes and health outcomes in infants and preschool children: Summary of an evidence report.
| Autor: | Beauchesne AR; School of Medicine, Tufts University, Boston, Massachusetts, USA., Cara KC; School of Medicine, Tufts University, Boston, Massachusetts, USA.; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA., Krobath DM; School of Medicine, Tufts University, Boston, Massachusetts, USA.; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA., Penkert LP; School of Medicine, Tufts University, Boston, Massachusetts, USA.; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA., Shertukde SP; School of Medicine, Tufts University, Boston, Massachusetts, USA.; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA., Cahoon DS; School of Medicine, Tufts University, Boston, Massachusetts, USA.; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA., Prado B; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA., Li R; School of Medicine, Tufts University, Boston, Massachusetts, USA.; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA., Yao Q; School of Medicine, Tufts University, Boston, Massachusetts, USA., Huang J; School of Medicine, Tufts University, Boston, Massachusetts, USA.; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA., Reh T; School of Medicine, Tufts University, Boston, Massachusetts, USA., Chung M; School of Medicine, Tufts University, Boston, Massachusetts, USA.; Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Annals of medicine [Ann Med] 2022 Dec; Vol. 54 (1), pp. 2278-2301. |
| DOI: | 10.1080/07853890.2022.2111602 |
| Abstrakt: | Background: A systematic review was commissioned to support an international expert group charged to update the Food and Agriculture Organisation of the United Nations (FAO)/World Health Organisation (WHO)'s vitamin D intake recommendations for children aged 0-4 years. Materials and Methods: Multiple electronic databases were searched to capture studies published from database inception to the 2 nd week of June 2020 according to key questions formulated by the FAO/WHO. Relevant studies were summarised and synthesised by key questions and by health outcomes using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach. Results: The 146 included studies examined the effects of different vitamin D intake levels on a variety of health outcomes (e.g. infectious disease, growth, neurodevelopment, rickets, and bone mineral density), and on outcomes for setting vitamin D upper limits (e.g. hypercalcemia, hypercalciuria, and nephrocalcinosis). For most outcomes, the strength of evidence was low or very low . Evidence was rated moderate for the effect of daily vitamin D supplementation on raising serum 25(OH)D concentrations, and a random-effects meta-regression analysis of 28 randomised controlled trials (mostly in infants 0-12 months) showed that each 100 IU/d increase in vitamin D supplementation was associated with an average of 1.92 (95% CI 0.28, 3.56) nmol/L increase in achieved 25-hydroxy-vitaminn D (25[OH]D) concentration ( n = 53 intervention arms; p = .022) with large residual heterogeneity ( I 2 = 99.39%). Evidence was very low on two of the upper limit outcomes - hypercalcemia and hypercalciuria. Conclusions: The evidence report provided the expert group with a foundation and core set of data to begin their work to set vitamin D nutrient reference values. To move the field forward, future studies should use standardised 25(OH)D assay measurements and should examine the relationship between long-term vitamin D status and health outcomes.Key MessagesResults of a large complex systematic review suggest the current totality of evidence from trials and prospective observational studies do not reach sufficient certainty level to support a causal relationship between vitamin D intake and asthma, wheeze, eczema, infectious diseases, or rickets (most trials reported no rickets) in generally healthy infants and young children.In this systematic review, the only body of evidence that reached a moderate level of certainty was regarding the effect of daily vitamin D supplementation (vitamin D |
| Databáze: | MEDLINE |
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