Altered visual entrainment in patients with Alzheimer's disease: magnetoencephalography evidence.

Autor:	Springer SD; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA., Wiesman AI; College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., May PE; College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., Schantell M; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA., Johnson HJ; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA., Willett MP; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA., Castelblanco CA; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA., Eastman JA; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA., Christopher-Hayes NJ; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA., Wolfson SL; College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., Johnson CM; College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., Murman DL; College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., Wilson TW; Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
Jazyk:	angličtina
Zdroj:	Brain communications [Brain Commun] 2022 Aug 01; Vol. 4 (4), pp. fcac198. Date of Electronic Publication: 2022 Aug 01 (Print Publication: 2022).
DOI:	10.1093/braincomms/fcac198
Abstrakt:	Recent research has indicated that rhythmic visual entrainment may be useful in clearing pathological protein deposits in the central nervous system of mouse models of Alzheimer's disease. However, visual entrainment studies in human patients with Alzheimer's disease are rare, and as such the degree to which these patients exhibit aberrations in the neural tracking of rhythmic visual stimuli is unknown. To fill this gap, we recorded magnetoencephalography during a 15 Hz visual entrainment paradigm in amyloid-positive patients on the Alzheimer's disease spectrum and compared their neural responses to a demographically matched group of biomarker-negative healthy controls. Magnetoencephalography data were imaged using a beamformer and virtual sensor data were extracted from the peak visual entrainment responses. Our results indicated that, relative to healthy controls, participants on the Alzheimer's disease spectrum exhibited significantly stronger 15 Hz entrainment in primary visual cortices relative to a pre-stimulus baseline period. However, the two groups exhibited comparable absolute levels of neural entrainment, and higher absolute levels of entertainment predicted greater Mini-mental Status Examination scores, such that those patients whose absolute entrainment amplitude was closer to the level seen in controls had better cognitive function. In addition, 15 Hz periodic activity, but not aperiodic activity, during the pre-stimulus baseline period was significantly decreased in patients on the Alzheimer's disease spectrum. This pattern of results indicates that patients on the Alzheimer's disease spectrum exhibited increased visual entrainment to rhythmic stimuli and that this increase is likely compensatory in nature. More broadly, these results show that visual entrainment is altered in patients with Alzheimer's disease and should be further examined in future studies, as changes in the capacity to entrain visual stimuli may prove useful as a marker of Alzheimer's disease progression. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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