Autoimmune Myelofibrosis in a 12-Year-old Male With Monosomy 7, Systemic Lupus Erythematous and Lupus Nephritis: A Case Report and Review of the Literature.
| Autor: | Español MG; Department of Pediatrics, Louisiana State University Health Science Center and Children's Hospital., Ehlayel AM; Department of Pediatrics, Children's Hospital, New Orleans, LA., Alicea Marrero MM; Department of Pediatrics, Louisiana State University Health Science Center and Children's Hospital., Gardner RV; Department of Pediatrics, Louisiana State University Health Science Center and Children's Hospital., Velez MC; Department of Pediatrics, Louisiana State University Health Science Center and Children's Hospital. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2023 Jan 01; Vol. 45 (1), pp. e1-e3. Date of Electronic Publication: 2022 Aug 11. |
| DOI: | 10.1097/MPH.0000000000002523 |
| Abstrakt: | Complete or partial loss of chromosome 7 is a common and well-known cytogenetic abnormality associated with preleukemic myelodysplasia and myeloid leukemia but not with autoimmune myelofibrosis. Detection of this molecular change represents poor prognosis. When malignant transformation occurs, the condition tends to be chemotherapy-resistant requiring haematopoietic stem cell transplantation (HSCT) to obtain a cure. Disappearance after immunosuppressive therapy has been documented in children with hematological disorders but not in association with cyclophosphamide and systemic lupus erythematous.We present the interesting case of a 12-year-old male with monosomy 7, systemic lupus erythematous, and lupus nephritis with the resolution of the monosomy 7 and autoimmune myelofibrosis after treatment with cyclophosphamide, along with a review of the literature. Competing Interests: M.C.V. is a principal investigator for clinical trials sponsored by NovoNordisk and Pfizer, with funds directed to educational funds in the division. The remaining authors declare no conflict of interest. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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