Venous thromboembolic and hemorrhagic events after meningioma surgery: A single-center retrospective cohort study of risk factors.

Autor: Lasica N; Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia., Djilvesi D; Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia., Papic V; Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia., Karan M; Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway., Jelaca B; Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia., Golubovic J; Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia., Pajicic F; Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia., Medic-Stojanoska M; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.; Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Novi Sad, Serbia., Vulekovic P; Clinic of Neurosurgery, Clinical Center of Vojvodina, Novi Sad, Serbia.; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia., Rasulic L; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.; Clinic for Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Aug 16; Vol. 17 (8), pp. e0273189. Date of Electronic Publication: 2022 Aug 16 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0273189
Abstrakt: Microsurgical resection of meningiomas in a majority of cases leads to a favorable outcome. Therefore, severe postoperative adverse events are less acceptable. The main purpose of this study was to investigate the incidence of symptomatic venous thromboembolism (VTE) and hemorrhagic complications in patients after operative treatment of intracranial meningiomas and to identify the risk factors in this patient subgroup. Of 106 patients undergoing elective craniotomy for meningioma overall incidence of symptomatic VTE was noted in 5.7% (six patients). For the risk-factor analysis older age (57.20 ± 11.60 vs. 71.00 ± 0.90 years, p < 0.001), higher body mass index (27.60 ± 4.80 vs. 33.16 ± 0.60 kg/m2, p < 0.001), WHO grade II (3.00% vs. 33.33%, p = 0.02), lower intraoperative blood loss (466.00 ± 383.70 vs. 216.70 ± 68.30 mL, p < 0.001), bedridden status and neurologic deficit (0.00% vs. 33.33%, p = 0.003 and 38.00% vs. 100.00%, p = 0.004) were associated with greater VTE risk. No risk factors for hemorrhagic complications were identified on univariate analysis. In conclusion, the incidence of VTE in meningioma patients is not negligible. Identified risk factors should be taken into account in the decision-making process for chemoprophylaxis when the risk of bleeding decreases.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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