Global multi-center and multi-modal magnetic resonance imaging study of obsessive-compulsive disorder: Harmonization and monitoring of protocols in healthy volunteers and phantoms.

Autor:	Pouwels PJW; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Vriend C; Department of Psychiatry, Department of Anatomy and Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Liu F; Columbia University Irving Medical Center, Columbia University, New York State Psychiatric Institute, New York, NY, USA., de Joode NT; Department of Psychiatry, Department of Anatomy and Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands., Otaduy MCG; Department of Radiology, LIM44, Institute, Hospital Das Clinicas-HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil., Pastorello B; Department of Radiology, LIM44, Institute, Hospital Das Clinicas-HCFMUSP, University of Sao Paulo Medical School, Sao Paulo, Brazil., Robertson FC; Cape Universities Body Imaging Centre, University of Cape Town, Cape Town, South Africa., Venkatasubramanian G; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India., Ipser J; Department of Psychiatry, SAMRC Unit on Risk & Resilience in Mental Disorders, Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Lee S; Columbia University Irving Medical Center, Columbia University, New York State Psychiatric Institute, New York, NY, USA., Batistuzzo MC; Obsessive-Compulsive Spectrum Disorders Program, Departmento de Psiquiatria da Faculdade de Medicina, LIM23, Hospital Das Clinicas HCFMUSP, Universidade de São Paulo, Sao Paulo, SP, Brazil.; Department of Methods and Techniques in Psychology, Pontifical Catholic University, Sao Paulo, SP, Brazil., Hoexter MQ; Obsessive-Compulsive Spectrum Disorders Program, Departmento de Psiquiatria da Faculdade de Medicina, LIM23, Hospital Das Clinicas HCFMUSP, Universidade de São Paulo, Sao Paulo, SP, Brazil., Lochner C; Department of Psychiatry, SAMRC Unit on Risk & Resilience in Mental Disorders, Stellenbosch University, Cape Town, South Africa., Miguel EC; Obsessive-Compulsive Spectrum Disorders Program, Departmento de Psiquiatria da Faculdade de Medicina, LIM23, Hospital Das Clinicas HCFMUSP, Universidade de São Paulo, Sao Paulo, SP, Brazil., Narayanaswamy JC; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India., Rao R; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India., Janardhan Reddy YC; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India., Shavitt RG; Obsessive-Compulsive Spectrum Disorders Program, Departmento de Psiquiatria da Faculdade de Medicina, LIM23, Hospital Das Clinicas HCFMUSP, Universidade de São Paulo, Sao Paulo, SP, Brazil., Sheshachala K; National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India., Stein DJ; Department of Psychiatry, SAMRC Unit on Risk & Resilience in Mental Disorders, Neuroscience Institute, University of Cape Town, Cape Town, South Africa., van Balkom AJLM; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam Public Health Research Institute, Specialised Mental Health Care, Amsterdam, The Netherlands., Wall M; Columbia University Irving Medical Center, Columbia University, New York State Psychiatric Institute, New York, NY, USA., Simpson HB; Columbia University Irving Medical Center, Columbia University, New York State Psychiatric Institute, New York, NY, USA., van den Heuvel OA; Department of Psychiatry, Department of Anatomy and Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	International journal of methods in psychiatric research [Int J Methods Psychiatr Res] 2023 Mar; Vol. 32 (1), pp. e1931. Date of Electronic Publication: 2022 Aug 15.
DOI:	10.1002/mpr.1931
Abstrakt:	Objectives: We describe the harmonized MRI acquisition and quality assessment of an ongoing global OCD study, with the aim to translate representative, well-powered neuroimaging findings in neuropsychiatric research to worldwide populations. Methods: We report on T1-weighted structural MRI, resting-state functional MRI, and multi-shell diffusion-weighted imaging of 140 healthy participants (28 per site), two traveling controls, and regular phantom scans. Results: Human image quality measures (IQMs) and outcome measures showed smaller within-site variation than between-site variation. Outcome measures were less variable than IQMs, especially for the traveling controls. Phantom IQMs were stable regarding geometry, SNR, and mean diffusivity, while fMRI fluctuation was more variable between sites. Conclusions: Variation in IQMs persists, even for an a priori harmonized data acquisition protocol, but after pre-processing they have less of an impact on the outcome measures. Continuous monitoring IQMs per site is valuable to detect potential artifacts and outliers. The inclusion of both cases and healthy participants at each site remains mandatory. (© 2022 The Authors. International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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