A low-power stretchable neuromorphic nerve with proprioceptive feedback.

Autor: Lee Y; Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea.; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Liu Y; Department of Bioengineering, Stanford University, Stanford, CA, USA.; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore., Seo DG; Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea., Oh JY; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Kim Y; Department of Electrical Engineering, Stanford University, Stanford, CA, USA., Li J; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Kang J; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Kim J; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Mun J; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Foudeh AM; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Bao Z; Department of Chemical Engineering, Stanford University, Stanford, CA, USA. zbao@stanford.edu., Lee TW; Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea. twlees@snu.ac.kr.; School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea. twlees@snu.ac.kr.; Institute of Engineering Research, Research Institute of Advanced Materials, Soft Foundry, Seoul National University, Seoul, Republic of Korea. twlees@snu.ac.kr.
Jazyk: angličtina
Zdroj: Nature biomedical engineering [Nat Biomed Eng] 2023 Apr; Vol. 7 (4), pp. 511-519. Date of Electronic Publication: 2022 Aug 15.
DOI: 10.1038/s41551-022-00918-x
Abstrakt: By relaying neural signals from the motor cortex to muscles, devices for neurorehabilitation can enhance the movement of limbs in which nerves have been damaged as a consequence of injuries affecting the spinal cord or the lower motor neurons. However, conventional neuroprosthetic devices are rigid and power-hungry. Here we report a stretchable neuromorphic implant that restores coordinated and smooth motions in the legs of mice with neurological motor disorders, enabling the animals to kick a ball, walk or run. The neuromorphic implant acts as an artificial efferent nerve by generating electrophysiological signals from excitatory post-synaptic signals and by providing proprioceptive feedback. The device operates at low power (~1/150 that of a typical microprocessor system), and consists of hydrogel electrodes connected to a stretchable transistor incorporating an organic semiconducting nanowire (acting as an artificial synapse), connected via an ion gel to an artificial proprioceptor incorporating a carbon nanotube strain sensor (acting as an artificial muscle spindle). Stretchable electronics with proprioceptive feedback may inspire the further development of advanced neuromorphic devices for neurorehabilitation.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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