A 3D printed pulmonary mock loop for hemodynamic studies in congenital heart disease.

Autor:	Conijn M; Wilhelmina Children's Hospital, University Medical Center Utrecht, Department Pediatric Cardiology, Utrecht, The Netherlands., Wintermans LM; Wilhelmina Children's Hospital, University Medical Center Utrecht, Department Pediatric Cardiology, Utrecht, The Netherlands., Metselaar R; Wilhelmina Children's Hospital, University Medical Center Utrecht, Department Pediatric Cardiology, Utrecht, The Netherlands., Ruisch J; Wilhelmina Children's Hospital, University Medical Center Utrecht, Department Pediatric Cardiology, Utrecht, The Netherlands., Bax EA; Wilhelmina Children's Hospital, University Medical Center Utrecht, Department Pediatric Cardiology, Utrecht, The Netherlands., van Egmond CAW; Wilhelmina Children's Hospital, University Medical Center Utrecht, Department Pediatric Cardiology, Utrecht, The Netherlands., Nieuwenstein B; Wilhelmina Children's Hospital, University Medical Center Utrecht, Department Pediatric Cardiology, Utrecht, The Netherlands., Warmerdam EG; Wilhelmina Children's Hospital, University Medical Center Utrecht, Department Pediatric Cardiology, Utrecht, The Netherlands., Krings GJ; Wilhelmina Children's Hospital, University Medical Center Utrecht, Department Pediatric Cardiology, Utrecht, The Netherlands.
Jazyk:	angličtina
Zdroj:	Biomedical physics & engineering express [Biomed Phys Eng Express] 2022 Sep 05; Vol. 8 (6). Date of Electronic Publication: 2022 Sep 05.
DOI:	10.1088/2057-1976/ac8993
Abstrakt:	Background . With the increasing survival of the congenital heart disease population, there is a growing need for in-depth understanding of blood circulation in these patients. Mock loops provide the opportunity for comprehensive hemodynamic studies without burden and risks for patients. This study aimed to evaluate the ability of the presented mock loop to mimic the hemodynamics of the pulmonary circulation with and without stenosis and the MR compatibility of the system. Methods . A pulsatile pump with two chambers, separated by a flexible membrane, was designed and 3D printed. A cough assist device applied an alternating positive and negative pressure on the membrane. One adult, and three pediatric pulmonary bifurcations were 3D printed and incorporated in the setup. Two pediatric models had a 50% stenosis of the left branch. Bilateral compliance chambers allowed for individual compliance tuning. A reservoir determined the diastolic pressure. Two carbon heart valves guaranteed unidirectional flow. The positive pressure on the cough assist device was tuned until an adequate stroke volume was reached with a frequency of 60 bpm. Flow and pressure measurements were performed on the main pulmonary artery and the two branches. The MR compatibility of the setup was evaluated. Results . A stroke volume with a cardiac index of 2 l min -1 m -2 was achieved in all models. Physiological pressure curves were generated in both normal and stenotic models. The mock loop was MR compatible. Conclusion. This MR compatible mock loop, closely resembles the pulmonary circulation thereby providing a controllable environment for hemodynamic studies. (© 2022 IOP Publishing Ltd.)
Databáze:	MEDLINE
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