Development of a diarrhoea severity scoring scale in a passive health facility-based surveillance system.

Autor: St Jean DT; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America., Chilyabanyama ON; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia., Bosomprah S; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia.; Department of Biostatistics, School of Public Health, University of Ghana, Ghana, Accra., Asombang M; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia., Velu RM; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia., Chibuye M; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia., Mureithi F; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia., Sukwa N; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia., Chirwa M; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia., Mokha P; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia., Chilengi R; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia., Simuyandi M; Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Aug 15; Vol. 17 (8), pp. e0272981. Date of Electronic Publication: 2022 Aug 15 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0272981
Abstrakt: Background: Diarrhoeal disease remains a leading cause of death among children mostly in low and middle-income countries. Factors contributing to disease severity are complex and there is currently no consensus on a scoring tool for use in community-based studies.
Methods: Data were collected during a passive surveillance system in an outpatient health facility in Lusaka, Zambia from March 2019 to July 2019. Diarrhea episodes were assessed for severity using an in-house severity scoring tool (CIDRZ) and previously published scores (Vesikari, Clark, CODA, and DHAKA). The CIDRZ score was constructed using fieldworker-reported clinical signs and exploratory factor analysis. We used precision-recall curves measuring severe diarrhoea (i.e., requiring intravenous rehydration or referred for hospital admission) to determine the best performing scores. Then, we used Cronbach's alpha to assess the scale's internal consistency. Finally, we used Cohen's kappa to assess agreement between the scores.
Results: Of 110 diarrhea episodes, 3 (3%) required intravenous rehydration or were referred for hospital admission. The precision-recall area under the curve of each score as a predictor of severe diarrhoea requiring intravenous rehydration or hospital admission was 0.26 for Vesikari, 0.18 for CODA, 0.24 for Clark, 0.59 for DHAKA, and 0.59 for CIDRZ. The CIDRZ scale had substantial reliability and performed similarly to the DHAKA score.
Conclusions: Diarrhoea severity scores focused on characteristics specific to dehydration status may better predict severe diarrhea among children in Lusaka. Aetiology-specific scoring tools may not be appropriate for use in community healthcare settings. Validation studies for the CIDRZ score in diverse settings and with larger sample sizes are warranted.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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