Dipole-Dipole and Anion-π + Interaction Manipulation Synergistically Enhance Intrinsic Antibacterial Activities of AIEgens.

Autor: Jiang G; College of Chemistry and Chemical Engineering, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, P. R. China., Hu R; State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, P. R. China.; School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, P. R. China., Li C; College of Chemistry and Chemical Engineering, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, P. R. China., Gong J; College of Chemistry and Chemical Engineering, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, P. R. China., Wang J; College of Chemistry and Chemical Engineering, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, P. R. China., Lam JWY; The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology Clear Water Bay, Kowloon, Hong Kong, P. R. China., Qin A; State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, P. R. China., Zhong Tang B; School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong Shenzhen, Guangdong, 518172, P. R. China.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Nov 11; Vol. 28 (63), pp. e202202388. Date of Electronic Publication: 2022 Sep 02.
DOI: 10.1002/chem.202202388
Abstrakt: Pathogenic bacteria infections, especially multidrug resistant bacteria infections have aroused worldwide attention due to their severe threats to human beings. Thus, the development of highly effective antibacterial reagents is very important. However, the design of antimicrobials is still quite challenging for the lack of a universal design strategy. Here, a synergistic manipulation strategy of dipole-dipole and anion-π + interaction is proposed for constructing highly efficient antimicrobials with aggregation-induced emission (AIE) feature. Firstly, four anion-π + -type AIE luminogens were designed and synthesized. Due to the electron-donating and hydrophilic characteristic of methoxy groups, 3MOTPO containing three methoxy groups showed the largest dipole moment (5.06 Debye) and dual anion-π + interactions in the solid state. Driven by both dipole-dipole and anion-π + interactions, 3MOTPO showed the strongest bacterial binding ability and the best antibacterial activities (MIC 90 =3.76 μM). The work offers a deep insight into the rational design of highly efficient antimicrobials for luminescence-guided antibacterial study.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
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