Genomic surveillance of SARS-CoV-2 in Puerto Rico enabled early detection and tracking of variants.

Autor: Santiago GA; Centers for Disease Control and Prevention, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector Borne Diseases, Dengue Branch, San Juan, Puerto Rico., Flores B; Centers for Disease Control and Prevention, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector Borne Diseases, Dengue Branch, San Juan, Puerto Rico., González GL; Centers for Disease Control and Prevention, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector Borne Diseases, Dengue Branch, San Juan, Puerto Rico., Charriez KN; Centers for Disease Control and Prevention, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector Borne Diseases, Dengue Branch, San Juan, Puerto Rico., Huertas LC; University of Puerto Rico-Río Piedras, Department of Biology, Molecular Sciences and Research Center, San Juan, Puerto Rico., Volkman HR; Centers for Disease Control and Prevention, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector Borne Diseases, Dengue Branch, San Juan, Puerto Rico., Van Belleghem SM; University of Puerto Rico-Río Piedras, Department of Biology, Molecular Sciences and Research Center, San Juan, Puerto Rico., Rivera-Amill V; Ponce Health Sciences University, Ponce Research Institute, Department of Basic Sciences, Ponce, Puerto Rico., Adams LE; Centers for Disease Control and Prevention, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector Borne Diseases, Dengue Branch, San Juan, Puerto Rico., Marzán M; Puerto Rico Department of Health, Epidemiology Office, San Juan, Puerto Rico., Hernández L; Puerto Rico Department of Health, Epidemiology Office, San Juan, Puerto Rico., Cardona I; Puerto Rico Department of Health, Epidemiology Office, San Juan, Puerto Rico., O'Neill E; Centers for Disease Control and Prevention, Office of Island Affairs, Center for State, Tribal, Local, and Territorial Support, Atlanta, GA USA., Paz-Bailey G; Centers for Disease Control and Prevention, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector Borne Diseases, Dengue Branch, San Juan, Puerto Rico., Papa R; University of Puerto Rico-Río Piedras, Department of Biology, Molecular Sciences and Research Center, San Juan, Puerto Rico., Muñoz-Jordan JL; Centers for Disease Control and Prevention, National Centers for Emerging and Zoonotic Infectious Diseases, Division of Vector Borne Diseases, Dengue Branch, San Juan, Puerto Rico.
Jazyk: angličtina
Zdroj: Communications medicine [Commun Med (Lond)] 2022 Aug 11; Vol. 2, pp. 100. Date of Electronic Publication: 2022 Aug 11 (Print Publication: 2022).
DOI: 10.1038/s43856-022-00168-7
Abstrakt: Background: Puerto Rico has experienced the full impact of the COVID-19 pandemic. Since SARS-CoV-2, the virus that causes COVID-19, was first detected on the island in March of 2020, it spread rapidly though the island's population and became a critical threat to public health.
Methods: We conducted a genomic surveillance study through a partnership with health agencies and academic institutions to understand the emergence and molecular epidemiology of the virus on the island. We sampled COVID-19 cases monthly over 19 months and sequenced a total of 753 SARS-CoV-2 genomes between March 2020 and September 2021 to reconstruct the local epidemic in a regional context using phylogenetic inference.
Results: Our analyses reveal that multiple importation events propelled the emergence and spread of the virus throughout the study period, including the introduction and spread of most SARS-CoV-2 variants detected world-wide. Lineage turnover cycles through various phases of the local epidemic were observed, where the predominant lineage was replaced by the next competing lineage or variant after ~4 months of circulation locally. We also identified the emergence of lineage B.1.588, an autochthonous lineage that predominated in Puerto Rico from September to December 2020 and subsequently spread to the United States.
Conclusions: The results of this collaborative approach highlight the importance of timely collection and analysis of SARS-CoV-2 genomic surveillance data to inform public health responses.
Competing Interests: Competing interestsThe authors declare no competing interests.
(© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022.)
Databáze: MEDLINE
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