Analysis of immunization time, amplitude, and adverse events of seven different vaccines against SARS-CoV-2 across four different countries.

Autor:	Romero-Ibarguengoitia ME; Research Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo Leon, Mexico.; Vicerrectoría de Ciencias de la Salud, Escuela de Medicina, Universidad de Monterrey, San Pedro Garza García, Mexico., González-Cantú A; Research Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo Leon, Mexico.; Vicerrectoría de Ciencias de la Salud, Escuela de Medicina, Universidad de Monterrey, San Pedro Garza García, Mexico., Pozzi C; Instituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy., Levi R; Instituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Mollura M; Department of Electronic, Information and Bioengineering, Politecnico di Milano, Milan, Italy., Sarti R; Instituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Sanz-Sánchez MÁ; Research Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo Leon, Mexico.; Vicerrectoría de Ciencias de la Salud, Escuela de Medicina, Universidad de Monterrey, San Pedro Garza García, Mexico., Rivera-Salinas D; Research Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo Leon, Mexico.; Vicerrectoría de Ciencias de la Salud, Escuela de Medicina, Universidad de Monterrey, San Pedro Garza García, Mexico., Hernández-Ruíz YG; Research Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo Leon, Mexico.; Vicerrectoría de Ciencias de la Salud, Escuela de Medicina, Universidad de Monterrey, San Pedro Garza García, Mexico., Armendariz-Vázquez AG; Research Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo Leon, Mexico.; Vicerrectoría de Ciencias de la Salud, Escuela de Medicina, Universidad de Monterrey, San Pedro Garza García, Mexico., Del Rio-Parra GF; Research Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo Leon, Mexico.; Vicerrectoría de Ciencias de la Salud, Escuela de Medicina, Universidad de Monterrey, San Pedro Garza García, Mexico., Barco-Flores IA; Research Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo Leon, Mexico., González-Facio R; Research Department, Hospital Clínica Nova de Monterrey, San Nicolás de los Garza, Nuevo Leon, Mexico., Azzolini E; Instituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Barbieri R; Department of Electronic, Information and Bioengineering, Politecnico di Milano, Milan, Italy., de Azevedo Dias AR; Health Department, Ternium Brazil, Rio de Janeiro, Brazil., Henriques Guimarães Júnior M; Research Department, Fundação São Francisco Xavier, Ipatinga, Brazil., Bastos-Borges A; Research Department, Fundação São Francisco Xavier, Ipatinga, Brazil., Acciardi C; Health Secretary, Unidad Hospitalaria San José, Campana, Argentina., Paez-Bo G; Laboratory Department, Hospital Interzonal General de Agudos San Felipe, San Nicolás de los Arroyos, Argentina., Teixeira MM; Biochemistry and Immunology Department, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Rescigno M; Instituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2022 Jul 28; Vol. 13, pp. 894277. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.894277
Abstrakt:	Background: Scarce information exists in relation to the comparison of seroconversion and adverse events following immunization (AEFI) with different SARS-CoV-2 vaccines. Our aim was to correlate the magnitude of the antibody response to vaccination with previous clinical conditions and AEFI. Methods: A multicentric comparative study where SARS-CoV-2 spike 1-2 IgG antibodies IgG titers were measured at baseline, 21-28 days after the first and second dose (when applicable) of the following vaccines: BNT162b2 mRNA, mRNA-1273, Gam-COVID-Vac, Coronavac, ChAdOx1-S, Ad5-nCoV and Ad26.COV2. Mixed model and Poisson generalized linear models were performed. Results: We recruited 1867 individuals [52 (SD 16.8) years old, 52% men]. All vaccines enhanced anti-S1 and anti-S2 IgG antibodies over time (p<0.01). The highest increase after the first and second dose was observed in mRNA-1273 (p<0.001). There was an effect of previous SARS-CoV-2 infection; and an interaction of age with previous SARS-CoV-2 infection, Gam-COVID-Vac and ChAdOx1-S (p<0.01). There was a negative correlation of Severe or Systemic AEFI (AEs) of naïve SARS-CoV-2 subjects with age and sex (p<0.001); a positive interaction between the delta of antibodies with Gam-COVID-Vac (p=0.002). Coronavac, Gam-COVID-Vac and ChAdOx1-S had less AEs compared to BNT162b (p<0.01). mRNA-1273 had the highest number of AEFIs. The delta of the antibodies showed an association with AEFIs in previously infected individuals (p<0.001). Conclusions: The magnitude of seroconversion is predicted by age, vaccine type and SARS-CoV-2 exposure. AEs are correlated with age, sex, and vaccine type. The delta of the antibody response only correlates with AEs in patients previously exposed to SARS-CoV-2. Registration Number: ClinicalTrials.gov, identifier NCT05228912. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Romero-Ibarguengoitia, González-Cantú, Pozzi, Levi, Mollura, Sarti, Sanz-Sánchez, Rivera-Salinas, Hernández-Ruíz, Armendariz-Vázquez, Del Rio-Parra, Barco-Flores, González-Facio, Azzolini, Barbieri, de Azevedo Dias, Henriques Guimarães Júnior, Bastos-Borges, Acciardi, Paez-Bo, Teixeira and Rescigno.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu