The Role of Leptin in Systemic Lupus Erythematosus: Is It Still a Mystery?

Autor:	Villa N; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Badla O; General Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Goit R; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Saddik SE; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Dawood SN; Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Rabih AM; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Mohammed A; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Raman A; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Uprety M; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Calero MJ; Gynecology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Villanueva MRB; Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Joshaghani N; Psychiatry and Behavioral Sciences, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Mohammed L; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Jul 11; Vol. 14 (7), pp. e26751. Date of Electronic Publication: 2022 Jul 11 (Print Publication: 2022).
DOI:	10.7759/cureus.26751
Abstrakt:	Systemic lupus erythematosus (SLE) is a chronic inflammatory connective tissue disease with varying clinical manifestations. Recent studies have proposed that leptin may be related to SLE development. This study aims to assess current information regarding the relationship between leptin and SLE. A systematic search was done using PubMed, Google Scholar, ScienceDirect, Epistemonikos, and Cochrane Library databases. Studies published in the English language in the last 10 years were selected based on predefined eligibility criteria. The quality of the studies was evaluated using the Newcastle-Ottawa Scale and the Assessment of Multiple Systematic Reviews 2 tool. A total of 12 studies were included in this systematic review. These included systematic reviews/meta-analyses, cross-sectional studies, and case-control studies . Based on the findings of this review, we conclude thatleptin is significantly elevated in SLE patients; however, it does not seem to correlate with disease activity. The exact mechanism of leptin in the pathogenesis of the disease remains unknown and further research is needed regarding this aspect. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Villa et al.)
Databáze:	MEDLINE
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