Copper-Catalyzed One-Pot Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from Arylacetic Acids and Hydrazides via Dual Oxidation.
| Autor: | Lekkala C; Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam 530003, India., Bodala V; Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam 530003, India., Yettula K; Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam 530003, India., Karasala BK; Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam 530003, India., Podugu RL; Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam 530003, India., Vidavalur S; Department of Organic Chemistry & FDW, Andhra University, Visakhapatnam 530003, India. |
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| Jazyk: | angličtina |
| Zdroj: | ACS omega [ACS Omega] 2022 Jul 27; Vol. 7 (31), pp. 27157-27163. Date of Electronic Publication: 2022 Jul 27 (Print Publication: 2022). |
| DOI: | 10.1021/acsomega.2c01586 |
| Abstrakt: | A simple and efficient protocol has been developed to access symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles from arylacetic acids and hydrazides via copper-catalyzed dual oxidation under an oxygen atmosphere. Oxidative decarboxylation of arylacetic acids and oxidative functionalization of the imine C-H bond are the key steps. This is the first example of the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles through dual oxidation in one-pot. Avoidance of the expensive ligand and high yield of the products are advantageous features of the developed method. Competing Interests: The authors declare no competing financial interest. (© 2022 The Authors. Published by American Chemical Society.) |
| Databáze: | MEDLINE |
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