Immunoglobulin γ chain allotypes and humoral immunity to HSV1 in Parkinson's disease.

Autor: Pandey JP; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA. Electronic address: pandeyj@musc.edu., Agostini S; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy., Namboodiri AM; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA., Mancuso R; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy., Guerini FR; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy., Meloni M; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy., Costa AS; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2022 Oct 15; Vol. 371, pp. 577948. Date of Electronic Publication: 2022 Aug 06.
DOI: 10.1016/j.jneuroim.2022.577948
Abstrakt: The aim of this investigation was to determine if particular immunoglobulin GM (γ marker) alleles and genotypes were associated with Parkinson's disease (PD) and whether they contributed to the interindividual differences in the level of antibodies to herpes simplex virus type 1 (HSV1), which has been implicated in PD pathology. Using a case-control study design, 94 PD patients and 157 controls were characterized for anti-HSV1 IgG antibodies and genotyped for GM alleles expressed on IgG1 (3,17) and IgG2 (23 +, 23-). The homozygosity for the GM 3 and GM 23 alleles was significantly associated with susceptibility to PD (p = 0.004, 0.018, respectively). Also, GM 23 genotypes were significantly associated with anti-HSV1 IgG antibody levels in patients (p = 0.0021), but not in controls. These results suggest that GM genes may act as effect modifiers of the reported HSV1-PD association.
Competing Interests: Declaration of Competing Interest The authors have no competing financial interests.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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