THE IMPACT OF THE VITREOMACULAR INTERFACE ON FUNCTIONAL AND ANATOMICAL OUTCOMES IN DIABETIC MACULAR EDEMA TREATED WITH THREE DIFFERENT ANTI-VEGF AGENTS: Post Hoc Analysis of The Protocol T Study.

Autor:	Mylonas G; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; and., Najeeb BH; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; and., Goldbach F; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; and., Deak GG; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; and., Michl M; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; and., Brugger J; Center for Medical Statistics, Informatics and Intelligent Systems, Section for Medical Statistics, Medical University of Vienna, Vienna, Austria., Schmidt-Erfurth U; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; and., Gerendas BS; Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; and.
Jazyk:	angličtina
Zdroj:	Retina (Philadelphia, Pa.) [Retina] 2022 Nov 01; Vol. 42 (11), pp. 2066-2074.
DOI:	10.1097/IAE.0000000000003594
Abstrakt:	Purpose: To investigate the impact of baseline vitreomacular interface status on treatment outcomes in patients treated with three different anti-vascular endothelial growth factors for diabetic macular edema. Methods: Post hoc analysis from patients enrolled in the DRCR.net Protocol T study. Optical coherence tomography images were analyzed at baseline and at the end of follow-up to identify the presence of complete vitreomacular adhesion, partial vitreomacular adhesion, vitreomacular traction syndrome, and complete posterior vitreous detachment. Results: Six hundred and twenty-nine eyes were eligible for the study based on the study criteria. Complete adhesion eyes gained on average +3.7 more ETDRS letters compared with the complete posterior vitreous detachment group at the end of the 12 months follow-up ( P < 0.001). Baseline vitreomacular interface status had no significant influence on central subfield thickness at 12 months ( P = 0.144). There was no difference between the treatment arms based on effect of baseline vitreomacular interface status on best-corrected visual acuity gain. Conclusion: This study provides evidence that vitreomacular interface status affects functional outcomes in diabetic macular edema patients treated with anti-vascular endothelial growth factor injections. The presence of complete or partial vitreomacular adhesion at baseline may be associated with a larger treatment benefit than those with complete posterior vitreous detachment.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu