Regulatory T-cell therapy approaches.
| Autor: | McCallion O; Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Bilici M; Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Hester J; Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Issa F; Translational Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Clinical and experimental immunology [Clin Exp Immunol] 2023 Mar 16; Vol. 211 (2), pp. 96-107. |
| DOI: | 10.1093/cei/uxac078 |
| Abstrakt: | Regulatory T cells (Tregs) have enormous therapeutic potential to treat a variety of immunopathologies characterized by aberrant immune activation. Adoptive transfer of ex vivo expanded autologous Tregs continues to progress through mid- to late-phase clinical trials in several disease spaces and has generated promising preliminary safety and efficacy signals to date. However, the practicalities of this strategy outside of the clinical trial setting remain challenging. Here, we review the current landscape of regulatory T-cell therapy, considering emergent approaches and technologies presenting novel ways to engage Tregs, and reflect on the progress necessary to deliver their therapeutic potential to patients. (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Immunology.) |
| Databáze: | MEDLINE |
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