Synthesis of 4-trifluoromethyl-2 H -chromenes via the reaction of 2-(trifluoroacetyl)phenols with vinyltriphenylphosphonium chloride.

Autor: Golubev AS; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov St. 28, GSP-1, Moscow, Russian Federation. golubev@ineos.ac.ru., Ostapchuk PN; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov St. 28, GSP-1, Moscow, Russian Federation. golubev@ineos.ac.ru., Strelkova TV; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov St. 28, GSP-1, Moscow, Russian Federation. golubev@ineos.ac.ru., Kagramanov ND; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov St. 28, GSP-1, Moscow, Russian Federation. golubev@ineos.ac.ru., Suponitsky KY; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov St. 28, GSP-1, Moscow, Russian Federation. golubev@ineos.ac.ru.; G.V. Plekhanov Russian University of Economics, 36 Stremyannyi Line, 117997, Moscow, Russia., Takazova RU; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov St. 28, GSP-1, Moscow, Russian Federation. golubev@ineos.ac.ru., Chkanikov ND; A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov St. 28, GSP-1, Moscow, Russian Federation. golubev@ineos.ac.ru.
Jazyk: angličtina
Zdroj: Organic & biomolecular chemistry [Org Biomol Chem] 2022 Aug 31; Vol. 20 (34), pp. 6809-6820. Date of Electronic Publication: 2022 Aug 31.
DOI: 10.1039/d2ob01177h
Abstrakt: Substituted on the benzene ring 4-CF 3 -2 H -chromenes have been prepared from substituted 2-(trifluoroacetyl)phenols and vinyltriphenylphosphonium chloride according to the Schweizer protocol in moderate to excellent yields. The influence of the type and the position of aromatic ring substituents on yields of 4-CF 3 -2 H -chromenes have been investigated. It has been shown that 4-CF 3 -2 H -chromenes are convenient precursors to 4-CF 3 -coumarins.
Databáze: MEDLINE
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