Serological Evidence and Self-reported Outcomes in Patients with Adrenal Insufficiency during the First Waves of COVID-19 in North-East Italy.

Autor:	Sabbadin C; Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy., Falb MP; Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy., Voltan G; Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy.; Department of Medicine DIMED, University of Padova, Padova, Italy., Tizianel I; Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy.; Department of Medicine DIMED, University of Padova, Padova, Italy., Padoan A; Department of Medicine DIMED, University of Padova, Padova, Italy.; Laboratory Medicine, University-Hospital of Padova, Padova, Italy., Betterle C; Department of Medicine DIMED, University of Padova, Padova, Italy., Basso D; Department of Medicine DIMED, University of Padova, Padova, Italy.; Laboratory Medicine, University-Hospital of Padova, Padova, Italy., Plebani M; Department of Medicine DIMED, University of Padova, Padova, Italy.; Laboratory Medicine, University-Hospital of Padova, Padova, Italy., Barbot M; Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy.; Department of Medicine DIMED, University of Padova, Padova, Italy., Scaroni C; Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy.; Department of Medicine DIMED, University of Padova, Padova, Italy., Ceccato F; Endocrine Disease Unit, University-Hospital of Padova, Padova, Italy.; Department of Medicine DIMED, University of Padova, Padova, Italy.
Jazyk:	angličtina
Zdroj:	Endocrine, metabolic & immune disorders drug targets [Endocr Metab Immune Disord Drug Targets] 2024; Vol. 24 (14), pp. 1677-1685.
DOI:	10.2174/1871530322666220811103755
Abstrakt:	Objective: COVID-19 is a potentially serious new infection first reported in North East Italy in Spring, 2020. Patients with adrenal insufficiency (AI) have a known increased risk of infections that could precipitate to adrenal crisis. Even COVID-19-related psycho-social impact could affect their health, requiring a dynamic adaptation of daily glucocorticoid (GC) therapy. The aim of this study was to evaluate the incidence of COVID-19 infection and self-reported outcomes in AI patients after the first pandemic waves. Methods: It was an open-label, cross-sectional monocentric study on 84 (65 primary, 19 secondary) AI patients resident in Veneto and followed-up in our clinical Endocrine Unit. All patients underwent serological investigation of anti-SARS-CoV2 IgG, answered the purpose-built "ADDICOVID" questionnaire in August, 2020, and were re-contacted to reevaluate COVID-19 infection occurrence in March-April, 2021. Results: All patients resulted negative to the serological test for anti-SARS-CoV2 IgG at the end of the first pandemic wave. After the third wave, COVID-19 infection occurred in 8 patients without the need for hospitalization. Half patients felt an increased risk of COVID-19 infection, significantly associated with increased stress and GC stress dose. Only one patient reported stress-correlated adrenal crisis. The majority of AI workers changed working habits, significantly reducing COVID- 19-related stress. Conclusion: AI patients did not show an increased incidence of COVID-19, but the perception of increased COVID-19 infection risk significantly impacted their psychological well-being, working habits, and GC daily doses. Therapeutic patient education is crucial, especially for AI workers, to prevent and treat situations that could lead to an adrenal crisis. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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