Association of Autonomic Activation with traumatic reminder challenges in posttraumatic stress disorder: A co-twin control study.

Autor: Perez Alday EA; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, Georgia, USA., Da Poian G; Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland., Levantsevych O; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA., Murrah N; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA., Shallenberger L; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA., Alkhalaf M; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA., Haffar A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA., Kaseer B; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA., Ko YA; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA., Goldberg J; Seattle Epidemiologic Research and Information Center, United States Department of Veterans Affairs Office of Research and Development, Seattle, Washington, USA., Smith N; Seattle Epidemiologic Research and Information Center, United States Department of Veterans Affairs Office of Research and Development, Seattle, Washington, USA.; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Lampert R; Yale University School of Medicine, New Haven, Connecticut, USA., Bremner JD; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.; Atlanta Veterans Affairs Health Care System, Decatur, Georgia, USA., Clifford GD; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, Georgia, USA.; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA., Vaccarino V; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA., Shah AJ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.; Atlanta Veterans Affairs Health Care System, Decatur, Georgia, USA.; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Psychophysiology [Psychophysiology] 2023 Feb; Vol. 60 (2), pp. e14167. Date of Electronic Publication: 2022 Aug 12.
DOI: 10.1111/psyp.14167
Abstrakt: Post-traumatic stress disorder (PTSD) has been associated with cardiovascular disease (CVD), but the mechanisms remain unclear. Autonomic dysfunction, associated with higher CVD risk, may be triggered by acute PTSD symptoms. We hypothesized that a laboratory-based trauma reminder challenge, which induces acute PTSD symptoms, provokes autonomic dysfunction in a cohort of veteran twins. We investigated PTSD-associated real-time physiologic changes with a simulation of traumatic experiences in which the twins listened to audio recordings of a one-minute neutral script followed by a one-minute trauma script. We examined two heart rate variability metrics: deceleration capacity (DC) and logarithmic low frequency (log-LF) power from beat-to-beat intervals extracted from ambulatory electrocardiograms. We assessed longitudinal PTSD status with a structured clinical interview and the severity with the PTSD Symptoms Scale. We used linear mixed-effects models to examine twin dyads and account for cardiovascular and behavioral risk factors. We examined 238 male Veteran twins (age 68 ± 3 years old, 4% black). PTSD status and acute PTSD symptom severity were not associated with DC or log-LF measured during the neutral session, but were significantly associated with lower DC and log-LF during the traumatic script listening session. Long-standing PTSD was associated with a 0.38 (95% confidence interval, -0.83,-0.08) and 0.79 (-1.30,-0.29) standardized unit lower DC and log-LF, respectively, compared to no history of PTSD. Traumatic reminders in patients with PTSD lead to real-time autonomic dysregulation and suggest a potential causal mechanism for increased CVD risk, based on the well-known relationships between autonomic dysfunction and CVD mortality.
(© 2022 Society for Psychophysiological Research.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje