Pancreatic Cancer and the Obesity Epidemic: A Narrative Review.
| Autor: | Poman DS; Research, Smolensk State Medical University, Smolensk, RUS., Motwani L; Research and Development, Smt. Nathiba Hargovandas Lakhmichand (NHL) Municipal Medical College, Ahmedabad, IND., Asif N; Research, Ras Al Khaimah (RAK) College of Medical Sciences, Ras Al Khaimah, ARE., Patel A; Research, Gujarat Medical Education & Research Society (GMERS) Medical College, Gotri, Vadodara, IND., Vedantam D; Internal Medicine, Kamineni Academy of Medical Sciences and Research Center, Hyderabad, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Jul 08; Vol. 14 (7), pp. e26654. Date of Electronic Publication: 2022 Jul 08 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.26654 |
| Abstrakt: | Pancreatic cancer (PC) is one of the most frequent causes of death. It usually affects older individuals with incidence closely approaching mortality due to its early asymptomatic feature and highly metastatic nature. Multiple risk factors such as family history, smoking, and germline mutations are associated with PC development, with obesity being one of the controllable factors. This review article focuses on the compilation of various studies to help establish a correlation between obesity or an increased body mass index and PC development. Hence, in this review, we have summarised multiple biological mechanisms of PC development induced by obesity, including insulin resistance, inflammation, beta-cell dysfunction, and oxidative stress, to prove that their correlation when combined with other factors, such as smoking, alcohol and chronic pancreatitis, may increase its risk. We have also reviewed potential diagnostic and screening techniques, such as evaluating precancerous lesions in high-risk patients and management plans discussing upcoming advances in treatment tactics such as neoadjuvant therapy, to reduce post-operative complications. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Poman et al.) |
| Databáze: | MEDLINE |
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