The neurobiology of misophonia and implications for novel, neuroscience-driven interventions.

Autor:	Neacsiu AD; Duke Center for Misophonia and Emotion Regulation, Duke Brain Stimulation Research Center, Department of Psychiatry and Behavioral Neuroscience, School of Medicine, Duke University, Durham, NC, United States., Szymkiewicz V; Department of Psychology and Neuroscience, Duke University, Durham, NC, United States., Galla JT; Department of Psychology and Neuroscience, Duke University, Durham, NC, United States., Li B; Department of Psychology and Neuroscience, Duke University, Durham, NC, United States., Kulkarni Y; Department of Psychology and Neuroscience, Duke University, Durham, NC, United States., Spector CW; Department of Philosophy, Duke University, Durham, NC, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2022 Jul 25; Vol. 16, pp. 893903. Date of Electronic Publication: 2022 Jul 25 (Print Publication: 2022).
DOI:	10.3389/fnins.2022.893903
Abstrakt:	Decreased tolerance in response to specific every-day sounds (misophonia) is a serious, debilitating disorder that is gaining rapid recognition within the mental health community. Emerging research findings suggest that misophonia may have a unique neural signature. Specifically, when examining responses to misophonic trigger sounds, differences emerge at a physiological and neural level from potentially overlapping psychopathologies. While these findings are preliminary and in need of replication, they support the hypothesis that misophonia is a unique disorder. In this theoretical paper, we begin by reviewing the candidate networks that may be at play in this complex disorder (e.g., regulatory, sensory, and auditory). We then summarize current neuroimaging findings in misophonia and present areas of overlap and divergence from other mental health disorders that are hypothesized to co-occur with misophonia (e.g., obsessive compulsive disorder). Future studies needed to further our understanding of the neuroscience of misophonia will also be discussed. Next, we introduce the potential of neurostimulation as a tool to treat neural dysfunction in misophonia. We describe how neurostimulation research has led to novel interventions in psychiatric disorders, targeting regions that may also be relevant to misophonia. The paper is concluded by presenting several options for how neurostimulation interventions for misophonia could be crafted. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Neacsiu, Szymkiewicz, Galla, Li, Kulkarni and Spector.)
Databáze:	MEDLINE
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