A case report of congenital factor X deficiency in an adult patient.

Autor:	Al-Ansari RY; Adult Hematology Unit, Internal Medicine Department, King Fahad Military Medical City (KFMMC), Dhahran, Kingdom of Saudi Arabia., Alofi G; Internal Medicine Department, King Fahad Military Medical City (KFMMC), Dhahran, Kingdom of Saudi Arabia., Aljarah N; Internal Medicine Department, King Fahad Military Medical City (KFMMC), Dhahran, Kingdom of Saudi Arabia., Woodman A; Vice Deanship of Postgraduate Studies and Research, Prince Sultan Military College of Health Sciences, Dhahran, Kingdom of Saudi Arabia.
Jazyk:	angličtina
Zdroj:	SAGE open medical case reports [SAGE Open Med Case Rep] 2022 Aug 03; Vol. 10, pp. 2050313X221116676. Date of Electronic Publication: 2022 Aug 03 (Print Publication: 2022).
DOI:	10.1177/2050313X221116676
Abstrakt:	Factor X deficiency is one of the rarest coagulation disorders representing 10% of all rare bleeding diseases with a frequency of 1:1,000,000. A 39-year-old male patient with no previous medical conditions was admitted to the hospital with a left carpal ganglion for surgical excision. Routine preoperative laboratory examination revealed a high international normalized ratio of 5.4 IU (0.8-1.1) and a prothrombin time of 72.2 s (10.9-13.6), with an isolated factor X level of less than 5%. Genetic testing for congenital factor X deficiency identified a homozygous mutation c.271 > A (p.Glu91). Vitamin K supplementation did not improve his international normalized ratio or increase factor X levels; hence, surgery was delayed. The patient was re-hospitalized to remove a wisdom tooth, during which fresh frozen plasma was administered. An allergic reaction complicated this procedure in the form of a rash on the body. As a result, the tooth was removed without active bleeding. This report presents a unique factor X deficiency case with limited treatment options to improve factor X levels after failed vitamin K administration and an allergic reaction to fresh frozen plasma. A physician's observation and ongoing follow-up were the only reasonable approaches in treating the patient with mild to moderate factor X deficiency due to lack of prothrombin complex concentrates or factor X replacement at the center at the time. Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2022.)
Databáze:	MEDLINE
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