Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light.

Autor:	Díaz NM; Department of Ophthalmology, University of Washington School of Medicine, Seattle, WA, United States., Gordon SA; Department of Ophthalmology, University of Washington School of Medicine, Seattle, WA, United States., Lang RA; Science of Light Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Buhr ED; Department of Ophthalmology, University of Washington School of Medicine, Seattle, WA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2022 Jul 22; Vol. 13, pp. 934591. Date of Electronic Publication: 2022 Jul 22 (Print Publication: 2022).
DOI:	10.3389/fphys.2022.934591
Abstrakt:	Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperatures. The preoptic area (POA) of the hypothalamus coordinates body temperature by responding to both external temperature cues and internal brain temperature. Here we describe an autonomous circadian clock system in the murine ventromedial POA (VMPO) in close proximity to cells which express the atypical violet-light sensitive opsin, Opn5. We analyzed the light-sensitivity and thermal-sensitivity of the VMPO circadian clocks ex vivo . The phase of the VMPO circadian oscillations was not influenced by light. However, the VMPO clocks were reset by temperature changes within the physiological internal temperature range. This thermal-sensitivity of the VMPO circadian clock did not require functional Opn5 expression or a functional circadian clock within the Opn5-expressing cells. The presence of temperature-sensitive circadian clocks in the VMPO provides an advancement in the understanding of mechanisms involved in the dynamic regulation of core body temperature. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Díaz, Gordon, Lang and Buhr.)
Databáze:	MEDLINE
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