| Autor: |
Araújo RG; Tecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing Monterrey, Monterrey 64849, Mexico., Zavala NR; Chemical & Biochemical Engineering Department, Tecnológico Nacional de México-Instituto Tecnológico de Durango (TecNM-ITD), Blvd. Felipe Pescador 1830 Ote. Durango, Durango 34080, Mexico., Castillo-Zacarías C; Universidad Autónoma de Nuevo León, Facultad de Ingeniería Civil, Departamento de Ingeniería Ambiental, Ciudad Universitaria S/N, San Nicolás de los Garza 66455, Mexico., Barocio ME; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico., Hidalgo-Vázquez E; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico., Parra-Arroyo L; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico., Rodríguez-Hernández JA; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico., Martínez-Prado MA; Chemical & Biochemical Engineering Department, Tecnológico Nacional de México-Instituto Tecnológico de Durango (TecNM-ITD), Blvd. Felipe Pescador 1830 Ote. Durango, Durango 34080, Mexico., Sosa-Hernández JE; Tecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing Monterrey, Monterrey 64849, Mexico., Martínez-Ruiz M; Tecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing Monterrey, Monterrey 64849, Mexico., Chen WN; School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637457, Singapore., Barceló D; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, IDAEA-CSIC, 08034 Barcelona, Spain.; Catalan Institute for Water Research (ICRA-CERCA), Parc Científic i Tecnològic de la Universitat de Girona, Edifici H2O, 17003 Girona, Spain.; Sustainability Cluster, School of Engineering, UPES, Dehradun 248007, India., Iqbal HMN; Tecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing Monterrey, Monterrey 64849, Mexico.; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico., Parra-Saldívar R; Tecnologico de Monterrey, Institute of Advanced Materials for Sustainable Manufacturing Monterrey, Monterrey 64849, Mexico.; Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico. |
| Abstrakt: |
Bionanocomposites based on natural bioactive entities have gained importance due to their abundance; renewable and environmentally benign nature; and outstanding properties with applied perspective. Additionally, their formulation with biological molecules with antimicrobial, antioxidant, and anticancer activities has been produced nowadays. The present review details the state of the art and the importance of this pyrrolic compound produced by microorganisms, with interest towards Serratia marcescens , including production strategies at a laboratory level and scale-up to bioreactors. Promising results of its biological activity have been reported to date, and the advances and applications in bionanocomposites are the most recent strategy to potentiate and to obtain new carriers for the transport and controlled release of prodigiosin. Prodigiosin, a bioactive secondary metabolite, produced by Serratia marcescens , is an effective proapoptotic agent against bacterial and fungal strains as well as cancer cell lines. Furthermore, this molecule presents antioxidant activity, which makes it ideal for treating wounds and promoting the general improvement of the immune system. Likewise, some of the characteristics of prodigiosin, such as hydrophobicity, limit its use for medical and biotechnological applications; however, this can be overcome by using it as a component of a bionanocomposite. This review focuses on the chemistry and the structure of the bionanocomposites currently developed using biorenewable resources. Moreover, the work illuminates recent developments in pyrrole-based bionanocomposites, with special insight to its application in the medical area. |
