The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief.

Autor:	Lucarini E; Department of Neuroscience, Psychology, Drug Research, and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy., Micheli L; Department of Neuroscience, Psychology, Drug Research, and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy., Pagnotta E; CREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, 40128 Bologna, Italy., Toti A; Department of Neuroscience, Psychology, Drug Research, and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy., Ferrara V; Department of Neuroscience, Psychology, Drug Research, and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy., Ciampi C; Department of Neuroscience, Psychology, Drug Research, and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy., Margiotta F; Department of Neuroscience, Psychology, Drug Research, and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy., Martelli A; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Centre Nutraceuticals and Food for Health-NUTRAFOOD, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Centre of Ageing Biology and Pathology, University of Pisa, 56126 Pisa, Italy., Testai L; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Centre Nutraceuticals and Food for Health-NUTRAFOOD, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Centre of Ageing Biology and Pathology, University of Pisa, 56126 Pisa, Italy., Calderone V; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Centre Nutraceuticals and Food for Health-NUTRAFOOD, University of Pisa, 56126 Pisa, Italy.; Interdepartmental Research Centre of Ageing Biology and Pathology, University of Pisa, 56126 Pisa, Italy., Matteo R; CREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, 40128 Bologna, Italy., Suriano S; CREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, 71122 Foggia, Italy., Troccoli A; CREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, 71122 Foggia, Italy., Pecchioni N; CREA-Council for Agricultural Research and Economics, Research Centre for Cereal and Industrial Crops, 71122 Foggia, Italy., Manera C; Department of Pharmacy, University of Pisa, 56126 Pisa, Italy., Mannelli LDC; Department of Neuroscience, Psychology, Drug Research, and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy., Ghelardini C; Department of Neuroscience, Psychology, Drug Research, and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2022 Jul 29; Vol. 14 (15). Date of Electronic Publication: 2022 Jul 29.
DOI:	10.3390/nu14153137
Abstrakt:	Brassicaceae are natural sources of bioactive compounds able to promote gut health. Belonging to this plant family, Camelina sativa is an ancient oil crop rich in glucosinolates, polyunsaturated fatty acids, and antioxidants that is attracting renewed attention for its nutraceutical potential. This work aimed at investigating the therapeutic effects of a defatted seed meal (DSM) of Camelina sativa on the colon damage and the persistent visceral hypersensitivity associated with colitis in rats. Inflammation was induced by the intrarectal injection of 2,4-dinitrobenzenesulfonic acid (DNBS). The acute administration of Camelina sativa DSM (0.1-1 g kg -1 ) showed a dose-dependent pain-relieving effect in DNBS-treated rats. The efficacy of the meal was slightly enhanced after bioactivation with myrosinase, which increased isothiocyanate availability, and drastically decreased by pre-treating the animals with the selective peroxisome proliferator-activated receptor alpha (PPAR α) receptor antagonist GW6471. Repeated treatments with Camelina sativa DSM (1 g kg -1 ) meal counteracted the development, as well as the persistence, of visceral hyperalgesia in DNBS-treated animals by reducing the intestinal inflammatory damage and preventing enteric neuron damage. In conclusion, Camelina sativa meal might be employed as a nutraceutical tool to manage persistent abdominal pain in patients and to promote gut healing.
Databáze:	MEDLINE
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