[S-methyl- 11 C]-L-methionine positron emission tomography/computed tomography imaging parameters to evaluate early response for esophageal cancer with neoadjuvant carbon ion radiotherapy.

Autor: Narushima K; Department of Surgery, Secomedic Hospital, Chiba, Japan.; Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.; Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST), QST Hospital, Chiba, Japan., Nishii R; Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST), Chiba, Japan. nishii.ryuichi@qst.go.jp., Okazumi S; Department of Surgery, Toho University Sakura Medical Center, Chiba, Japan., Shimada H; Department of Gastroenterological Surgery, Toho University Graduate School of Medicine, Tokyo, Japan., Akutsu Y; Miwa Central Clinic, Ibaraki, Japan., Maeda T; Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST), QST Hospital, Chiba, Japan., Yasuda S; Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST), QST Hospital, Chiba, Japan.; Department of Radiology, Chiba Rosai Hospital, Chiba, Japan., Yamada S; Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST), QST Hospital, Chiba, Japan., Shuto K; Department of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan., Tamura K; Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST), Chiba, Japan., Yamazaki K; Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST), Chiba, Japan., Shinoto M; Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST), QST Hospital, Chiba, Japan., Ishikawa H; Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology (QST), QST Hospital, Chiba, Japan., Mori M; Department of Surgery, Secomedic Hospital, Chiba, Japan., Matsubara H; Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Aug 11; Vol. 12 (1), pp. 13694. Date of Electronic Publication: 2022 Aug 11.
DOI: 10.1038/s41598-022-17962-x
Abstrakt: This study aimed to evaluate the uptake of the clinical effectiveness of [S-methyl- 11 C]-L-methionine positron emission tomography/computed tomography (MET PET/CT) in patients with esophageal cancer and to investigate MET PET/CT imaging parameters to assess early response for esophageal cancer with neoadjuvant carbon ion radiotherapy (CIRT). MET PET/CT scans were performed in nineteen patients before and 3 weeks after completion of CIRT. After Surgery, the effect of neoadjuvant CIRT was investigated by examining the relationship between each parameter of MET uptake and the histological assessment (grade and tumor residual ratio). Four parameters of MET uptake were the maximum and minimum standardized uptake values of pre and post CIRT (pre-SUVmax, pre-SUVmean, post-SUVmax, and post-SUVmean). MET PET/CT imaging of esophageal cancer was clearly demonstrated. The post-SUVmax was the most suitable parameter. When the cutoff value was set as post-SUVmax = 6.21, the sensitivity, the specificity, and the accuracy of Grades 3 were 100.0%, 63.6%, and 78.9%, respectively. And there was a positive relationship between the tumor residual ratio and post-SUVmax (R 2  = 0.38, p < 0.005). MET PET/CT is clinically useful for the assessment of early response to neoadjuvant CIRT in esophageal cancer. Particularly, post-SUVmax is considered a promising PET imaging parameter.
(© 2022. The Author(s).)
Databáze: MEDLINE
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